DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and dic1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001342791.1	Gene:	dic1 / 5802757	PomBaseID:	SPBC646.17c	Length:	544	Species:	Schizosaccharomyces pombe

Alignment Length:	313	Identity:	61/313 - (19%)
Similarity:	102/313 - (32%)	Gaps:	108/313 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 VTISNPTKY---VYTGG--KGCVKVWDISQ------------PGNKNPVSQLDCLQRDNYIRSVK 497
            :|:..|:.:   :..||  .|.|.:||:.|            .|:..||:.:      .||.:
pombe   246 ITVCKPSPFHPQLIAGGAYNGQVFLWDLRQGQYPVSFTTIISGGHLEPVTDI------TYINN-- 302

  Fly   498 LLPDGRTLIVGGEASNLSIWD-----LASPTPRIKAELTSAAPACYALAIS--PDSKVCFSC-CS 554
              |....::.......:.||:     ..|.|..:.:::.|::....|..:|  |::.:.|.. ..
pombe   303 --PPSNNIVTCSTDGLVHIWEPDMFSRPSETICLSSQVDSSSQCIPATCLSFIPENNMEFLVGAE 365

  Fly   555 DGNI--AVWDLHNEILVRQ-----FQGHTDGASCIDISPDGSR----------LWTGGLDNTVRS 602
            ||.:  .....::|....|     ::||....|.||:....|:          ..|...|.|||.
pombe   366 DGKLQRGYRSDYSETKAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEKNKDFALTSSFDWTVRL 430

  Fly   603 WDLREGRQLQQH------DFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCV 661
            |.....|  .||      |...|:. :..|.|                          ..|::.|
pombe   431 WQCSPSR--NQHELVPSNDLDEQVI-INSCKT--------------------------FTHKAMV 466

  Fly   662 LSLRFAACGKWFVS-----TGKDNL--LNAWRTPYGASIFQSKETSSVLSCDI 707
            ..:      ||.||     ...|.|  ||.|..        .|:..:.::.||
pombe   467 FDV------KWCVSEPCCFASVDALGNLNLWDL--------QKDVEAPVTSDI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	61/313 (19%)
		WD40 repeat	447..486	CDD:293791	12/52 (23%)
		WD40 repeat	494..532	CDD:293791	5/42 (12%)
		WD40 repeat	537..573	CDD:293791	8/45 (18%)
		WD40 repeat	580..615	CDD:293791	13/50 (26%)
		WD40 repeat	620..653	CDD:293791	2/32 (6%)
		WD40 repeat	661..695	CDD:293791	10/40 (25%)
		WD40 repeat	702..726	CDD:293791	2/6 (33%)
dic1	NP_001342791.1	WD40	223..536	CDD:330360	61/313 (19%)
		WD40 repeat	247..289	CDD:293791	9/41 (22%)
		WD40 repeat	294..339	CDD:293791	8/54 (15%)
		WD40 repeat	348..390	CDD:293791	7/41 (17%)
		WD40 repeat	397..453	CDD:293791	15/57 (26%)
		WD40 repeat	466..504	CDD:293791	11/51 (22%)
		WD40 repeat	511..535	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910