DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and tle2b

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_021329162.1	Gene:	tle2b / 564019	ZFINID:	ZDB-GENE-050208-677	Length:	763	Species:	Danio rerio

Alignment Length:	807	Identity:	472/807 - (58%)
Similarity:	553/807 - (68%)	Gaps:	121/807 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGP-PPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYV 64
            |||.. |||.   | .|....|||:.:||:||||||.||||||||:|||||||::|||||||||:
Zfish     1 MYPQG-RHPV---PLQPGQSFKFTVLETLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYI 61

  Fly    65 MYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQ 129
            ||||||||||:|||||.||.|||:.:..|::|||..:|||||:|||||||||||.|||.|||.||
Zfish    62 MYYEMSYGLNIEMHKQAEIVKRLSAICAQIIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQQ 126

  Fly   130 QHGIQQLLQQIHAQQVPGGP--PQPMG----------ALNPFGALGATMGLPHGPQGLLNKPPEH 182
                   ||.: :...||.|  |.|.|          ||.  ||||.|   .|    |.||...:
Zfish   127 -------LQHL-SHHTPGIPLTPHPSGLSLGGTSSLLALT--GALGVT---AH----LANKDERN 174

  Fly   183 HRPDIKPTGLEGPAAAEERLRNSVSPADREKYRTR-SPLDIEN-----DSKRRKDEK---LQ--- 235
            |   :.|..|...|.:..:   |||..|.:....| .|..:.:     |:|||:.|:   ||
Zfish   175 H---LDPEHLREGAPSRSK---SVSSTDSQAVEDRQGPSGVYSSQAGGDAKRRRCEEKDILQSHY 233

  Fly   236 EDEGEKSDQDLVVDVANEMESHSP------RPNGEHVSMEVRDRESLNGE--------------R 280
            :.:|:||:.:|||||:|| |:.||      .|:|..:...:..|:.|.|.              .
Zfish   234 DSDGDKSEDNLVVDVSNE-EASSPVGSAPLSPHGNGLDRALPLRKELPGSPSPPTASPPHSPTPG 297

  Fly   281 LEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPNAAA------PAPGV- 338
            ..|.::...|.:.|.|:||:||    ||  ..|...||.||    .|.|:.:.      ||...
Zfish   298 KNKDTAQTEKSQSPSSKSGNSS----PS--HHDPLTPGPPG----PPGPSTSCLRLVNKPASSAD 352

  Fly   339 -----NPKQMMPQGPP-----------------PAGYPGAPYQRPADPYQRPPSDPAYGRPPPMP 381
                 :|..|.|...|                 |.|:.|:....|    |...:..||.|.|.:.
Zfish   353 PLALRSPLTMTPGSYPAHFGVVSHAGLNGELASPGGFGGSLTLSP----QISAAASAYTRSPMVA 413

  Fly   382 YDPHAHVRTNGIPHPSAL---TGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSH 443
            |:..:|:|.:|:  .|:|   |.||||||||::.:|.:||||||||||:|.|||||||||:||||
Zfish   414 YESRSHLRPSGL--SSSLPGSTSGKPAYSFHVSADGQMQPVPFPPDALLGPGIPRHARQIHTLSH 476

  Fly   444 GEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVG 508
            ||||||||||..|::||||||||||||||||||:|:|::|||||.|||||||.|:||||||||||
Zfish   477 GEVVCAVTISTSTRHVYTGGKGCVKVWDISQPGSKSPMAQLDCLNRDNYIRSCKILPDGRTLIVG 541

  Fly   509 GEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQ 573
            ||||.|||||||:|||||||||||:||||||||||||:||||||||||||.||||||:.||||||
Zfish   542 GEASTLSIWDLATPTPRIKAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQ 606

  Fly   574 GHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMEN 638
            ||||||||||||.||::|||||||||||.||||||||||||||:||||||||||||:|||||||:
Zfish   607 GHTDGASCIDISNDGTKLWTGGLDNTVRCWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES 671

  Fly   639 SHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVL 703
            |:|||||.||||||||||||||||||:||.|||||||||||||||||||||||||||||||||||
Zfish   672 SNVEVLHVSKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVL 736

  Fly   704 SCDISTDDKYIVTGSGDKKATVYEVIY 730
            |||:|.|||||||||||||||||||:|
Zfish   737 SCDVSPDDKYIVTGSGDKKATVYEVVY 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	80/113 (71%)
		WD40	442..727	CDD:238121	253/284 (89%)
		WD40 repeat	447..486	CDD:293791	30/38 (79%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	31/35 (89%)
		WD40 repeat	580..615	CDD:293791	30/34 (88%)
		WD40 repeat	620..653	CDD:293791	28/32 (88%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	21/23 (91%)
tle2b	XP_021329162.1	TLE_N	1..128	CDD:309152	91/137 (66%)
		WD40	471..760	CDD:238121	256/288 (89%)
		WD40 repeat	480..519	CDD:293791	30/38 (79%)
		WD40 repeat	527..565	CDD:293791	33/37 (89%)
		WD40 repeat	570..606	CDD:293791	31/35 (89%)
		WD40 repeat	613..648	CDD:293791	30/34 (88%)
		WD40 repeat	653..686	CDD:293791	28/32 (88%)
		WD40 repeat	694..728	CDD:293791	31/33 (94%)
		WD40 repeat	735..759	CDD:293791	21/23 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	878	1.000	Inparanoid score	I384
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm25426
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980