DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and traf7

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001073654.1 Gene:traf7 / 563746 ZFINID:ZDB-GENE-070112-2212 Length:639 Species:Danio rerio


Alignment Length:205 Identity:54/205 - (26%)
Similarity:89/205 - (43%) Gaps:43/205 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   436 RQINTL-SHGEVVCAVTISNPTKYVYTGGKGCVKVWDI---------SQPGNKNPVSQLDCLQRD 490
            :::||: :|...||.:..|:  ..:::|....:|||||         ...|..:.|..|...|..
Zfish   439 QKVNTIRAHDNPVCTLVSSH--NMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVASQNH 501

  Fly   491 NY-----------IRSVK----LLPDGRTL---------IVGGEASNL-SIWDLASPTPRIKAEL 530
            .|           |||::    |...|.::         ||.|...|| .:||:.| ..:::. |
Zfish   502 LYSGSYQTIKIWDIRSLECVHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIES-KEQVRT-L 564

  Fly   531 TSAAPACYALAI--SPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWT 593
            |......||||:  :||....||...|.::.||.:.|.|..:....|....:.:.:|  ..||::
Zfish   565 TGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVS--RGRLFS 627

  Fly   594 GGLDNTVRSW 603
            |.:|:||:.|
Zfish   628 GAVDSTVKVW 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 52/198 (26%)
WD40 repeat 447..486 CDD:293791 12/47 (26%)
WD40 repeat 494..532 CDD:293791 13/51 (25%)
WD40 repeat 537..573 CDD:293791 13/37 (35%)
WD40 repeat 580..615 CDD:293791 8/24 (33%)
WD40 repeat 620..653 CDD:293791
WD40 repeat 661..695 CDD:293791
WD40 repeat 702..726 CDD:293791
traf7NP_001073654.1 RING 100..132 CDD:214546
Sina 141..>249 CDD:302762
Snapin_Pallidin 260..342 CDD:291383
WD40 <349..637 CDD:225201 53/203 (26%)
WD40 357..637 CDD:238121 53/203 (26%)
WD40 repeat 368..406 CDD:293791
WD40 repeat 412..446 CDD:293791 2/6 (33%)
WD40 repeat 451..486 CDD:293791 9/36 (25%)
WD40 repeat 493..525 CDD:293791 6/31 (19%)
WD40 repeat 531..565 CDD:293791 8/35 (23%)
WD40 repeat 573..608 CDD:293791 12/34 (35%)
WD40 repeat 615..637 CDD:293791 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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