DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and wdr74

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001070031.1	Gene:	wdr74 / 558996	ZFINID:	ZDB-GENE-060929-1138	Length:	375	Species:	Danio rerio

Alignment Length:	217	Identity:	46/217 - (21%)
Similarity:	92/217 - (42%)	Gaps:	13/217 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 GEVVCAVTISNPTK-YVYTGGK-GCVKVWDISQPGN-----KNPVSQLDCLQRDNYIRSVKLLPD 501
            |:.:|.:..:...: :|.|||| ..:||||:.:|..     ||.......::...::|.:..:.|
Zfish   125 GKDICKMRQNQSQRHHVATGGKENPLKVWDLEKPDKPIFTAKNVAHDWLEMRVPVWVRDISFIAD 189

  Fly   502 GRTLIVGGEASNLSIWDLASP--TPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLH 564
            ...::.......:.::|.::|  .|.::|:.........:|..|.|:.|..:  :.|.:|:.||.
Zfish   190 SDKIVTCTGHHKVRVYDPSTPQRRPVLEADFGEYPLTALSLPASQDAVVVGN--THGELAILDLR 252

  Fly   565 NEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTG 629
            ..::...|:|.......:...|....:.:.|||..:|...| |.|.||...:.....:.....:.
Zfish   253 KGLVRGCFKGLAGAVRGLQCHPSLPLVASCGLDRFLRVHSL-EDRSLQHKVYLKSRLNCVLLSSR 316

  Fly   630 DWLAVGMENSHVEVLHASKPDK 651
            | |....::..||.:.|.:.|:
Zfish   317 D-LESSSDSGDVEEVKAEEEDE 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	46/217 (21%)
		WD40 repeat	447..486	CDD:293791	13/45 (29%)
		WD40 repeat	494..532	CDD:293791	6/39 (15%)
		WD40 repeat	537..573	CDD:293791	8/35 (23%)
		WD40 repeat	580..615	CDD:293791	10/34 (29%)
		WD40 repeat	620..653	CDD:293791	6/32 (19%)
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
wdr74	NP_001070031.1	WD40 repeat	44..82	CDD:293791
		WD40	<52..325	CDD:225201	42/203 (21%)
		WD40 repeat	125..166	CDD:293791	12/40 (30%)
		WD40	137..>300	CDD:295369	37/165 (22%)
		WD40 repeat	182..219	CDD:293791	5/36 (14%)
		WD40 repeat	225..261	CDD:293791	8/37 (22%)
		WD40 repeat	267..309	CDD:293791	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910