DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and ATG16L1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001350671.1	Gene:	ATG16L1 / 55054	HGNCID:	21498	Length:	624	Species:	Homo sapiens

Alignment Length:	753	Identity:	148/753 - (19%)
Similarity:	251/753 - (33%)	Gaps:	274/753 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ERIKEEFNFL--QAQYHSI---KLECEK-----------------LSNEKTEMQRHYVMYYEMSY 71
            |.|..::|.|  ::..||:   ||:.||                 ..|:..||.:..:.:.|..
Human    33 EEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEEL- 96

  Fly    72 GLNVEMHKQT-EIAKRLNTLINQLLPFLQADHQQQV--------LQAVE---------RAKQVTM 118
               .|:||:. |:|:.:..|.||:   .:.|.:.|:        ||.:.         |.|...:
Human    97 ---TELHKKRGELAQLVIDLNNQM---QRKDREMQMNEAKIAECLQTISDLETECLDLRTKLCDL 155

  Fly   119 QELNLIIGHQQQHGIQQLLQQIHAQQVPGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHH 183
            :..|           |.|..:..|.|:            .|.||          :|.|.|..|.:
Human   156 ERAN-----------QTLKDEYDALQI------------TFTAL----------EGKLRKTTEEN 187

  Fly   184 RPDIKPTGLEGPAAAEERLRNSVSPADREKYRTRSPLDIEND-SKRRKDEKLQEDEGEKSDQDLV 247
                               :..|:....||.:..:.|:.||: ..||:..:||::..|.:.:.|.
Human   188 -------------------QELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLP 233

  Fly   248 VDVANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTK 312
            |:..:::|          |.::               .:|...:|..|.|
Human   234 VEQDDDIE----------VIVD---------------ETSDHTEETSPVR--------------- 258

  Fly   313 DMEKPGTPGAKARTPTPNAAAPAPGVNPKQMMPQG---PPPAGYPGAPYQRPADPYQRPPSDPAY 374
                     |.:|..|...:.||.|:........|   .|..|:..:             ||.|.
Human   259 ---------AISRAATKRLSQPAGGLLDSITNIFGLSESPLLGHHSS-------------SDAAR 301

  Fly   375 GRPP---PMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHAR 436
            .|..   |:|.|       |...||                 ||.:.|..|..||  .....|..
Human   302 RRSVSSFPVPQD-------NVDTHP-----------------GSGKEVRVPATAL--CVFDAHDG 340

  Fly   437 QINTLSHGEVVCAVTISNPTKYVYTGGKG-CVKVWDI---------SQPGNKNPVSQL------- 484
            ::|         ||..|..::.:.|||.. .||:|::         |..|:...::.:
Human   341 EVN---------AVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGS 396

  Fly   485 -------DCLQR----DNY------------IRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRI 526
                   |...|    |:|            :.|.|.|.|...::.|.....|.:|||.|   ::
Human   397 YLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS---KV 458

  Fly   527 KAELTSAAPACYALAISPDSKVCFSCC-----SDGNIAVWDLHNEILVRQFQ--GHTDGASCIDI 584
            ..:...|..:|       :..||...|     .|..|..||:.:|.:||:.:  |.   .:.:|:
Human   459 CIKTVFAGSSC-------NDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGK---ITALDL 513

  Fly   585 SPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLG-------YCPTGDWLAVGMENSHVE 642
            :|:.:.|.:...|:.::..|||.....|  .||:..|..|       :.|.|.::|.|.....:.
Human   514 NPERTELLSCSRDDLLKVIDLRTNAIKQ--TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLY 576

  Fly   643 V--LHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGK 678
            :  :...|.:|.....|.|.:.::.::..|...||..|
Human   577 IWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	29/134 (22%)
		WD40	442..727	CDD:238121	62/293 (21%)
		WD40 repeat	447..486	CDD:293791	11/62 (18%)
		WD40 repeat	494..532	CDD:293791	10/37 (27%)
		WD40 repeat	537..573	CDD:293791	11/40 (28%)
		WD40 repeat	580..615	CDD:293791	8/34 (24%)
		WD40 repeat	620..653	CDD:293791	8/41 (20%)
		WD40 repeat	661..695	CDD:293791	4/18 (22%)
		WD40 repeat	702..726	CDD:293791
ATG16L1	NP_001350671.1	ATG16	31..206	CDD:312208	43/231 (19%)
		WD40	<272..390	CDD:225201	34/165 (21%)
		WD40	332..622	CDD:238121	65/309 (21%)
		WD40 repeat	344..381	CDD:293791	10/36 (28%)
		WD40 repeat	387..423	CDD:293791	4/35 (11%)
		WD40 repeat	428..465	CDD:293791	10/39 (26%)
		WD40 repeat	473..503	CDD:293791	10/29 (34%)
		WD40 repeat	508..544	CDD:293791	8/37 (22%)
		WD40 repeat	554..590	CDD:293791	6/35 (17%)
		WD40 repeat	597..621	CDD:293791	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910