DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and poc1a

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001016608.1	Gene:	poc1a / 549362	XenbaseID:	XB-GENE-5767105	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	304	Identity:	67/304 - (22%)
Similarity:	125/304 - (41%)	Gaps:	47/304 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 IPRHARQINTLSHGEVVCAVTISNPTKYVYTGG-KGCVKVWDISQP-------GNKNPVSQLD-- 485
            :.||.:     .|.:.|..|..:..||.:.:|. ..|:.:|::...       |:|:.:..:|
Frog    10 LERHFK-----GHRDTVTTVDFNPNTKQLASGSMDSCLMIWNMKPQMRAYRFVGHKDAILSVDFS 69

  Fly   486 -------CLQRD---------------------NYIRSVKLLPDGRTLIVGGEASNLSIWDLASP 522
                   ...||                     ..:|||....||::|:...:...:.:|.:  .
Frog    70 PSGHLIASASRDKTVRLWVPSVKGESTVFKAHTGTVRSVSFSGDGQSLVTASDDKTIKVWTV--H 132

  Fly   523 TPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPD 587
            ..:....|............|||.::..|...|..|.:||..:...:..|..|....:.:|..|.
Frog   133 RQKFLFSLNQHINWVRCAKFSPDGRLIVSASDDKTIKLWDKTSRECIHSFCEHGGFVNFVDFHPS 197

  Fly   588 GSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIF-SLGYCPTGDWLAVGMENSHVEVLHASKPD- 650
            |:.:.....||||:.||:|..:.:|.:...|.:. ||.:.|:|::|.....:|.::||...:..
Frog   198 GTCIAAAATDNTVKVWDIRMNKLIQHYQVHSGVVNSLSFHPSGNYLITASNDSTLKVLDLLEGRL 262

  Fly   651 KYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIF 694
            .|.||.|:..|.|::|:..|::|.|.|.|..:..|:|.:.::.:
Frog   263 LYTLHGHQGPVTSVKFSREGEFFASGGSDEQVMVWKTNFDSASY 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	65/293 (22%)
		WD40 repeat	447..486	CDD:293791	10/55 (18%)
		WD40 repeat	494..532	CDD:293791	8/37 (22%)
		WD40 repeat	537..573	CDD:293791	8/35 (23%)
		WD40 repeat	580..615	CDD:293791	11/34 (32%)
		WD40 repeat	620..653	CDD:293791	8/34 (24%)
		WD40 repeat	661..695	CDD:293791	10/34 (29%)
		WD40 repeat	702..726	CDD:293791
poc1a	NP_001016608.1	WD40	10..298	CDD:238121	65/294 (22%)
		WD 1	16..55		8/38 (21%)
		WD40 repeat	21..58	CDD:293791	7/36 (19%)
		WD 2	58..97		5/38 (13%)
		WD40 repeat	64..100	CDD:293791	3/35 (9%)
		WD 3	100..139		7/40 (18%)
		WD40 repeat	105..141	CDD:293791	7/37 (19%)
		WD 4	142..181		8/38 (21%)
		WD40 repeat	148..182	CDD:293791	8/33 (24%)
		WD 5	184..223		11/38 (29%)
		WD40 repeat	189..225	CDD:293791	11/35 (31%)
		WD 6	226..265		9/38 (24%)
		WD40 repeat	231..267	CDD:293791	9/35 (26%)
		WD 7	268..307		11/39 (28%)
		WD40 repeat	273..297	CDD:293791	8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910