DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and tle2

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_012817170.1	Gene:	tle2 / 548559	XenbaseID:	XB-GENE-876620	Length:	789	Species:	Xenopus tropicalis

Alignment Length:	809	Identity:	473/809 - (58%)
Similarity:	551/809 - (68%)	Gaps:	120/809 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPS--PVRH-------PAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEK 56
            |:|.  |..|       .||.|||..  :|.|..:||:||||||.|||:||||:|||||||:.||
Frog    22 MFPQNRPPTHLQASVAAGAASGPPQS--LKLTYPETLDRIKEEFQFLQSQYHSLKLECEKLATEK 84

  Fly    57 TEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQEL 121
            ||:|||||||||||||||:|||||||||||||.:..||:|||..:|||||:|||||||||||.||
Frog    85 TEIQRHYVMYYEMSYGLNIEMHKQTEIAKRLNVICAQLVPFLSQEHQQQVVQAVERAKQVTMAEL 149

  Fly   122 NLIIGHQ---QQHGIQQLLQQIHAQQVPGGP--PQPMGALNPFGALGATMGLP----HGPQGLLN 177
            |..||.:   .|..:.||..|..:...|..|  |.| .:|.|.|...||....    .|..||
Frog   150 NAAIGVRFIPPQLTVHQLQAQHLSHHAPPIPLTPHP-SSLQPPGLAAATSASSLLALSGVLGL-- 211

  Fly   178 KPPEHHRPDIKPTGL---EGPAAAEERLR----NSVSPADREKYRTRSPLDIENDSKRRKDEKLQ 235
                       .|.|   ||.|.||.|.|    :.|:..:.|:.||.|  |..|.:|:||.|  :
Frog   212 -----------QTQLAVKEGLADAEHRERDPGPSCVTLPNGERVRTLS--DYLNSNKKRKTE--E 261

  Fly   236 EDEG-------EKSDQDLVVD----VANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGI 289
            :|.|       ::|:.:||||    ..:.:.|:|.|.||                 ::|||..
Frog   262 KDFGTDYGSDADRSEDNLVVDEDPASPHSVHSYSSRENG-----------------VDKPSLQ-- 307

  Fly   290 KQERPPS--RSGSSSSRSTPSLKTKD-----MEKPGTPGAKARTPTPNA--AAPAP-GVNPKQMM 344
            :::.||:  .|.:|||..:|| ::||     :||.||||.|:.||...:  ..|.| |.:..|..
Frog   308 RKDPPPASPNSMTSSSSVSPS-RSKDIPSQQVEKAGTPGLKSSTPNSQSDMNTPGPSGTSASQFR 371

  Fly   345 PQGPPPA----------------GYPGA-PYQRP------ADPY-----QRPPSDPA-----YGR 376
            .....||                |||.| ....|      |..|     ..|..:.|     |||
Frog   372 SISSKPAIDSLALGLRTPLGGQGGYPAAFSIAHPSVNADGAGAYAGLHLMSPQINGATAAGTYGR 436

  Fly   377 PPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTL 441
            .|.:.||||||:|..|...|.: ..||||||||::.:|.:||||||||||:|.||||||||::.|
Frog   437 SPLVSYDPHAHMRGLGAAIPGS-ASGKPAYSFHVSADGQMQPVPFPPDALIGSGIPRHARQLHVL 500

  Fly   442 SHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLI 506
            :||||||||||||.|::|||||||||||||:.|||.|.||:|||||.|||||||.|||||||:||
Frog   501 NHGEVVCAVTISNSTRHVYTGGKGCVKVWDVGQPGTKTPVAQLDCLNRDNYIRSCKLLPDGRSLI 565

  Fly   507 VGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQ 571
            ||||||.|||||||||||||||||||:||||||||||||:||||||||||||.||||.|:.||||
Frog   566 VGGEASTLSIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIVVWDLQNQTLVRQ 630

  Fly   572 FQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGM 636
            ||||||||||||||.||::|||||||||||.||||||||||||||:||||||||||||:||||||
Frog   631 FQGHTDGASCIDISHDGTKLWTGGLDNTVRCWDLREGRQLQQHDFNSQIFSLGYCPTGEWLAVGM 695

  Fly   637 ENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSS 701
            |:|:|||||.||||||||||||||||||:||:||||||||||||||||||||||||||||||:||
Frog   696 ESSNVEVLHVSKPDKYQLHLHESCVLSLQFASCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSS 760

  Fly   702 VLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            |||||:||||::|||||||||||||||||
Frog   761 VLSCDVSTDDQFIVTGSGDKKATVYEVIY 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	84/112 (75%)
		WD40	442..727	CDD:238121	250/284 (88%)
		WD40 repeat	447..486	CDD:293791	30/38 (79%)
		WD40 repeat	494..532	CDD:293791	34/37 (92%)
		WD40 repeat	537..573	CDD:293791	30/35 (86%)
		WD40 repeat	580..615	CDD:293791	30/34 (88%)
		WD40 repeat	620..653	CDD:293791	28/32 (88%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	20/23 (87%)
tle2	XP_012817170.1	TLE_N	22..172	CDD:281857	95/151 (63%)
		WD40	<501..787	CDD:225201	251/285 (88%)
		WD40	502..786	CDD:238121	250/283 (88%)
		WD40 repeat	506..545	CDD:293791	30/38 (79%)
		WD40 repeat	553..591	CDD:293791	34/37 (92%)
		WD40 repeat	596..632	CDD:293791	30/35 (86%)
		WD40 repeat	639..674	CDD:293791	30/34 (88%)
		WD40 repeat	679..712	CDD:293791	28/32 (88%)
		WD40 repeat	720..754	CDD:293791	31/33 (94%)
		WD40 repeat	761..785	CDD:293791	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3155
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	905	1.000	Inparanoid score	I367
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm47907
Panther	1	1.100	-	-	O	PTHR10814
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160