DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and WDR44

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_061918.3	Gene:	WDR44 / 54521	HGNCID:	30512	Length:	913	Species:	Homo sapiens

Alignment Length:	783	Identity:	142/783 - (18%)
Similarity:	236/783 - (30%)	Gaps:	309/783 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 PAAAEERLRN--------SVSPADREKYRTRSPLDIENDSKRRK----DEKLQE--DEGEKSDQD 245
            |..|...|.|        .|.|.:.:|..:::..: |.:.:.:|    ||..::  ||..|..|.
Human    97 PIVARTDLSNIPGLLAIDQVLPEESQKAESQNTFE-ETELELKKCFPSDETCEKPVDETTKLTQT 160

  Fly   246 LVVDVANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLK 310
            ...:..|.:|:.:...|.|  ::||:.    .|:.||..||.                    ||.
Human   161 SSTEQLNVLETETEVLNKE--AVEVKG----GGDVLEPVSSD--------------------SLS 199

  Fly   311 TKDME-----KPGTPGAKARTPTPNAAAPAPGVNPKQMMP-QGPPPAGYPGAPYQRPADPYQRPP 369
            |||..     .|..| .:..||.|:..|     :.|:.:| :.|||..:|        .|...||
Human   200 TKDFAAVEEVAPAKP-PRHLTPEPDIVA-----STKKPVPARPPPPTNFP--------PPRPPPP 250

  Fly   370 SDPAYGRPPP------MPYD----PHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSL-------- 416
            |.||   |||      :.::    |...|....|...|.||....:.|...:.:.||
Human   251 SRPA---PPPRKRKSELEFETLKTPDIDVPKENITSDSLLTASMASESTVKDSQPSLDLASATSG 312

  Fly   417 ------QPVPFPPDA------LVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKV 469
                  |.....||.      ::|...|| :.....|:..|::.:|.|.|    :.||.:..:.:
Human   313 DKIVTAQENGKAPDGQTVAGEVMGPQRPR-SNSGRELTDEEILASVMIKN----LDTGEEIPLSL 372

  Fly   470 WDISQPGNKNPVS-----------QLDCLQRD--------------------------------- 490
            .:...|...||::           ..|..|.|
Human   373 AEEKLPTGINPLTLHIMRRTKEYVSNDAAQSDDEEKLQSQPTDTDGGRLKQKTTQLKKFLGKSVK 437

  Fly   491 --------------NYIRSV-------------------------------------------KL 498
                          |.::||                                           |:
Human   438 RAKHLAEEYGERAINKVKSVRDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKV 502

  Fly   499 LPD-----------------GRTLIVGGEASNLSIWDL-------------------ASPTPRIK 527
            :.|                 ||.|...|:.:.:.||.|                   .||:|..:
Human   503 VQDLSGEHMGAVWTMKFSHCGRLLASAGQDNVVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQE 567

  Fly   528 AELTSAAP----ACYALAISPDSK--------VC--------------------FSCCSDGNIAV 560
            :..:|.:.    .|......||.|        .|                    .|...|..:.:
Human   568 SLSSSKSDTDTGVCSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRL 632

  Fly   561 WDLHNEILVRQFQGHTDGASCIDISPDGSRLW-TGGLDNTVRSWDLREGRQLQQHDFSSQ---IF 621
            |.:.....:..|| |.|..:.|...|...|.: :|.||..:|.|::.:.:....::...|   |.
Human   633 WHISRRECLCCFQ-HIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLIT 696

  Fly   622 SLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVS----------- 675
            :..:|..|.:..:|..:... :.:.::..||...:|   |.|.|    |:..|.
Human   697 AANFCQNGKYAVIGTYDGRC-IFYDTEHLKYHTQIH---VRSTR----GRNKVGRKITGIEPLPG 753

  Fly   676 ------TGKDNLLNAW-------RTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYE 727
                  |..|:.:..:       ...|...:    .:||.:....|.|..|:|:||.||...::.
Human   754 ENKILVTSNDSRIRLYDLRDLSLSMKYKGYV----NSSSQIKASFSHDFTYLVSGSEDKYVYIWS 814

  Fly   728 VIY 730
            ..:
Human   815 TYH 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	74/481 (15%)
		WD40 repeat	447..486	CDD:293791	8/49 (16%)
		WD40 repeat	494..532	CDD:293791	14/116 (12%)
		WD40 repeat	537..573	CDD:293791	8/63 (13%)
		WD40 repeat	580..615	CDD:293791	8/35 (23%)
		WD40 repeat	620..653	CDD:293791	5/32 (16%)
		WD40 repeat	661..695	CDD:293791	8/57 (14%)
		WD40 repeat	702..726	CDD:293791	8/23 (35%)
WDR44	NP_061918.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Binding activity	2..170		16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..348		36/160 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..480		0/20 (0%)
		WD 1	509..548		7/38 (18%)
		WD40	510..857	CDD:238121	57/321 (18%)
		WD40 repeat	514..562	CDD:293791	7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..593		8/35 (23%)
		WD 2	605..643		3/37 (8%)
		WD40 repeat	610..644	CDD:293791	3/33 (9%)
		WD 3	645..685		11/40 (28%)
		WD40 repeat	651..688	CDD:293791	8/36 (22%)
		WD 4	690..729		7/39 (18%)
		WD40 repeat	695..730	CDD:293791	6/35 (17%)
		WD 5	740..779		3/38 (8%)
		WD40 repeat	745..785	CDD:293791	3/43 (7%)
		WD 6	784..823		10/38 (26%)
		WD40 repeat	789..813	CDD:293791	8/23 (35%)
		WD 7	876..913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910