DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and PLRG1

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_002660.1 Gene:PLRG1 / 5356 HGNCID:9089 Length:514 Species:Homo sapiens


Alignment Length:554 Identity:125/554 - (22%)
Similarity:192/554 - (34%) Gaps:134/554 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 SKRRKDEKLQEDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSS-SGI 289
            |.:|..:....|.|:        .|..:.|||..:     :::::|:.   .|..|..|:| ..:
Human    17 SLKRTHDMFVADNGK--------PVPLDEESHKRK-----MAIKLRNE---YGPVLHMPTSKENL 65

  Fly   290 KQERPPSRSGSSSSRSTPSLKTKDME--KPGTPGAKARTPTPNAAAPAPGV-----NPKQMMPQG 347
            |::.|.:.:.|...:..|:.:.:::|  ..||      .|.|    |.|||     ...|.||..
Human    66 KEKGPQNATDSYVHKQYPANQGQEVEYFVAGT------HPYP----PGPGVALTADTKIQRMPSE 120

  Fly   348 PPPAGYPGA-PYQRPADPYQRPPSDPAYGRP----PPMPYDPHAHVRTNGIPHPSALTGGK---- 403
            ........| |.|..||..:..||...|..|    .|.|...::.|...|....|||...|    
Human   121 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTM 185

  Fly   404 PAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKG-CV 467
            |...:|            ||..|..| |..|.        |.|.| :.:....::..||... .:
Human   186 PKPQWH------------PPWKLYRV-ISGHL--------GWVRC-IAVEPGNQWFVTGSADRTI 228

  Fly   468 KVWD-------ISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPR 525
            |:||       :|..|:.:.|..:....|..|:.|.            ||...:..|||  ...:
Human   229 KIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSC------------GEDKQVKCWDL--EYNK 279

  Fly   526 IKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSR 590
            :.........|.|.|.:.|...|..:|..|....:||:..:..|....|||:..:.:.......:
Human   280 VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ 344

  Fly   591 LWTGGLDNTVRSWDLREGR---QLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKY 652
            :.||..|.|:|.|||..|:   .|..|..|.:             ||.:...|......| ||..
Human   345 IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR-------------AVVLHPRHYTFASGS-PDNI 395

  Fly   653 Q------------LHLHESCVLSLRFAACGKWFVSTGKDN---LLNAWRTPYGASIFQS------ 696
            :            |..|.:.:.:|...:.|  .:.:|.||   .|..|||.|.   ||.      
Human   396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTGYN---FQRVHAAVQ 455

  Fly   697 ----KETSSVLSCDISTDDKYIVTGSGDKKATVY 726
                ...|.:.:|.....:..::|...||...||
Human   456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 71/321 (22%)
WD40 repeat 447..486 CDD:293791 9/46 (20%)
WD40 repeat 494..532 CDD:293791 6/37 (16%)
WD40 repeat 537..573 CDD:293791 9/35 (26%)
WD40 repeat 580..615 CDD:293791 10/37 (27%)
WD40 repeat 620..653 CDD:293791 6/32 (19%)
WD40 repeat 661..695 CDD:293791 10/36 (28%)
WD40 repeat 702..726 CDD:293791 4/23 (17%)
PLRG1NP_002660.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 135..160 7/24 (29%)
WD40 196..490 CDD:238121 75/337 (22%)
WD 1 202..241 9/47 (19%)
WD40 repeat 209..244 CDD:293791 7/35 (20%)
WD 2 244..283 10/52 (19%)
WD40 repeat 250..286 CDD:293791 8/49 (16%)
WD 3 286..325 10/38 (26%)
WD40 repeat 291..327 CDD:293791 9/35 (26%)
WD 4 328..367 12/38 (32%)
WD40 repeat 334..369 CDD:293791 9/34 (26%)
WD 5 370..410 8/53 (15%)
WD40 repeat 375..410 CDD:293791 6/48 (13%)
WD 6 411..449 12/42 (29%)
WD40 repeat 416..455 CDD:293791 12/43 (28%)
WD 7 460..499 7/30 (23%)
WD40 repeat 465..489 CDD:293791 4/23 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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