DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and wds

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster

Alignment Length:	405	Identity:	85/405 - (20%)
Similarity:	151/405 - (37%)	Gaps:	73/405 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 MMPQGPPPAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYS 407
            |:|.|....|:||..:         ||..|.    |..|..|:: ::.|.:..|.|.|....:.|
  Fly     1 MVPIGAVHGGHPGVVH---------PPQQPL----PTAPSGPNS-LQPNSVGQPGATTSSNSSAS 51

  Fly   408 FHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTIS-NPTKYVYTGGKGCVKVW- 470
                .:.||...            |.:..:.....|.:.|.||..| |......:.....:|:|
  Fly    52 ----NKSSLSVK------------PNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWG 100

  Fly   471 ------DISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAE 529
                  :.:..|:|..:|            .|....|.|.|:.|.:...|.:|:|:  |.:....
  Fly   101 AYDGKFEKTISGHKLGIS------------DVAWSSDSRLLVSGSDDKTLKVWELS--TGKSLKT 151

  Fly   530 LTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTG 594
            |...:...:....:|.|.:..|...|.::.:||:.....::....|:|..|.:..:.|||.:.:.
  Fly   152 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 216

  Fly   595 GLDNTVRSWDLREGRQLQQ--HDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKP---DKYQL 654
            ..|...|.||...|:.|:.  .|.:..:..:.:.|.|.::.....::.:::...||.   ..|..
  Fly   217 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 281

  Fly   655 HLHES-CVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKE--------TSSVLSCDISTD 710
            |.:|. |:.:......|||.||..:||::..|.       .||||        |.:||.......
  Fly   282 HKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWN-------LQSKEVVQKLQGHTDTVLCTACHPT 339

  Fly   711 DKYIVTGSGDKKATV 725
            :..|.:.:.:...|:
  Fly   340 ENIIASAALENDKTI 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	65/306 (21%)
		WD40 repeat	447..486	CDD:293791	10/46 (22%)
		WD40 repeat	494..532	CDD:293791	10/37 (27%)
		WD40 repeat	537..573	CDD:293791	6/35 (17%)
		WD40 repeat	580..615	CDD:293791	10/36 (28%)
		WD40 repeat	620..653	CDD:293791	4/35 (11%)
		WD40 repeat	661..695	CDD:293791	8/33 (24%)
		WD40 repeat	702..726	CDD:293791	4/24 (17%)
wds	NP_001245503.1	WD40	64..358	CDD:238121	65/312 (21%)
		WD40 repeat	75..112	CDD:293791	7/36 (19%)
		WD40 repeat	118..154	CDD:293791	11/49 (22%)
		WD40 repeat	159..195	CDD:293791	6/35 (17%)
		WD40 repeat	202..237	CDD:293791	10/34 (29%)
		WD40 repeat	244..280	CDD:293791	4/35 (11%)
		WD40 repeat	288..325	CDD:293791	13/43 (30%)
		WD40 repeat	331..357	CDD:293791	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910