DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and poc1b

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_012814294.1	Gene:	poc1b / 448445	XenbaseID:	XB-GENE-944930	Length:	470	Species:	Xenopus tropicalis

Alignment Length:	340	Identity:	85/340 - (25%)
Similarity:	142/340 - (41%)	Gaps:	31/340 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 PAYSFHMNG-EGSLQPVPFPP----------DALVGV-GIPRHARQINTLSHGEVVCAVTISNPT 456
            ||...|..| :.::..|.|.|          ||.|.: .....:|......|.|.|..|..|...
Frog     8 PALQRHFKGHKDAVTYVDFSPDGKQLASSSADACVMIWNFKPQSRAYKYPGHKEAVTCVQFSPSG 72

  Fly   457 KYVYTGGKG-CVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLA 520
            ..|.:..|. .|::|   .|..|...|.|..  ....:|.|....||.|.|...:..::..|:|
Frog    73 HLVASSSKDRTVRLW---APNIKGESSVLKA--HTAVVRCVNFSSDGHTFITASDDKSIKAWNL- 131

  Fly   521 SPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDIS 585
             ...|....||...........|||.::..||..|..:.:||:.|.:.:..|..:...::.:|.:
Frog   132 -HRQRFLYSLTEHTNWVRCARFSPDGRLIASCSDDKTVRIWDITNRLCINTFVDYKGHSNYVDFN 195

  Fly   586 PDGSRLWTGGLDNTVRSWDLREGRQLQQHD-FSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKP 649
            |.|:.:.:.|:|:||:.||:|..:.||.:. .::.:.||.:.|:|::|.....:..|::|...:.
Frog   196 PMGTCVASAGVDSTVKVWDIRTNKLLQHYQVHNAGVNSLSFHPSGNYLLTASNDGTVKILDLLEG 260

  Fly   650 DK-YQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGA-SIFQSKETSSVLSC------- 705
            .. |.||.|:..|||:.|:..|..|.|...|..:..|:|.:.. :|.:..:.....:|
Frog   261 RLIYTLHGHQGPVLSVAFSKSGDQFASGATDAQVLVWKTNFDKYNIKEIVKLQQKRTCPEAPPHL 325

  Fly   706 -DISTDDKYIVTGSG 719
             ||.....::.|.||
Frog   326 NDIYPKTPHLHTSSG 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	74/290 (26%)
		WD40 repeat	447..486	CDD:293791	11/39 (28%)
		WD40 repeat	494..532	CDD:293791	10/37 (27%)
		WD40 repeat	537..573	CDD:293791	9/35 (26%)
		WD40 repeat	580..615	CDD:293791	12/34 (35%)
		WD40 repeat	620..653	CDD:293791	7/33 (21%)
		WD40 repeat	661..695	CDD:293791	11/34 (32%)
		WD40 repeat	702..726	CDD:293791	6/26 (23%)
poc1b	XP_012814294.1	WD40	12..298	CDD:238121	74/292 (25%)
		WD40 repeat	21..58	CDD:293791	7/36 (19%)
		WD40 repeat	64..100	CDD:293791	10/38 (26%)
		WD40 repeat	105..141	CDD:293791	9/37 (24%)
		WD40 repeat	148..183	CDD:293791	9/34 (26%)
		WD40 repeat	190..225	CDD:293791	12/34 (35%)
		WD40 repeat	231..267	CDD:293791	8/35 (23%)
		WD40 repeat	273..297	CDD:293791	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910