DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and Plap

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001245829.1 Gene:Plap / 43978 FlyBaseID:FBgn0024314 Length:787 Species:Drosophila melanogaster


Alignment Length:334 Identity:70/334 - (20%)
Similarity:112/334 - (33%) Gaps:93/334 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 HGEVVCAVTIS-NPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLI 506
            |...|||::.. .|...:........:||.||:.|:   ||.:.....:..:.:|..|.:.|..:
  Fly   107 HESTVCALSAGLEPRSLISGSWDKTARVWTISEAGD---VSFVALEGHEAAVWAVATLKEQRKYV 168

  Fly   507 VGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQ 571
            .||...|:..|:....    |..|......|....:..|:....||.:|..:..|:...| .||:
  Fly   169 TGGADRNIYYWNAKGE----KLRLLKGHTDCVRGVMGLDANTLLSCGNDAVLRFWNEDGE-CVRE 228

  Fly   572 FQGHTD---------------GASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ---HDFSS 618
            ..||::               ..||             |.|:|:|.|::..|.:|..   |...|
  Fly   229 MNGHSNYIYSMARNEALGDQVVVSC-------------GEDSTLRMWNVITGDELGAPIIHPGIS 280

  Fly   619 QIFSLGYCPTGDWLAVGMEN------SHVEVLHASK-----------PDKYQLH----------- 655
             ::|:.....|| :..|..:      |||....||:           ..|.|::           
  Fly   281 -VWSVTCLQNGD-IVTGCSDGVVRVFSHVPARQASEAVLKAFDLVVATRKSQINEEIGGVKKTDL 343

  Fly   656 ----------LHESCVLSLRFA----ACGKWFVSTGKDNLL-------NAWRTPYGASIFQSKET 699
                      ..|.....:|.|    .|..|  :.|..||:       ...::..|..:.:.||.
  Fly   344 PGPEALLSNGTREGQTKMVRHADGSVKCYTW--TLGNWNLVGDVTGATGGTQSNSGKKLHEGKEY 406

  Fly   700 SSVLSCDIS 708
            ..|.|.|||
  Fly   407 DFVFSVDIS 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 70/334 (21%)
WD40 repeat 447..486 CDD:293791 11/39 (28%)
WD40 repeat 494..532 CDD:293791 9/37 (24%)
WD40 repeat 537..573 CDD:293791 9/35 (26%)
WD40 repeat 580..615 CDD:293791 9/37 (24%)
WD40 repeat 620..653 CDD:293791 10/49 (20%)
WD40 repeat 661..695 CDD:293791 8/44 (18%)
WD40 repeat 702..726 CDD:293791 5/7 (71%)
PlapNP_001245829.1 WD40 <4..266 CDD:225201 39/179 (22%)
WD40 10..305 CDD:238121 47/220 (21%)
WD40 repeat 23..64 CDD:293791
WD40 repeat 70..106 CDD:293791
WD40 repeat 111..149 CDD:293791 11/40 (28%)
WD40 repeat 156..190 CDD:293791 9/37 (24%)
WD40 repeat 196..230 CDD:293791 8/34 (24%)
WD40 repeat 236..277 CDD:293791 9/53 (17%)
WD40 repeat 284..304 CDD:293791 3/20 (15%)
PFU 353..462 CDD:286196 16/65 (25%)
PUL 531..781 CDD:285517
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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