DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and CG6420

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001287545.1	Gene:	CG6420 / 43218	FlyBaseID:	FBgn0039451	Length:	909	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	90/428 - (21%)
Similarity:	132/428 - (30%)	Gaps:	177/428 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 PSRSGSSSSRSTPSLKTKDMEKP-------------GTP----GAKARTPTPNAAAPAPGVNPKQ 342
            |:|.|.||::|:|.::...:..|             |||    .|.|.|.|.|.::|
  Fly    35 PNRVGYSSNQSSPQVRVSMVTLPSPAQGKLGSDVGVGTPVGGGTAGANTTTTNGSSP-------- 91

  Fly   343 MMPQGPPPAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYS 407
                |..|.|..||                                 :..|.:..|  ||..::|
  Fly    92 ----GASPTGAAGA---------------------------------STAISNGGA--GGDYSHS 117

  Fly   408 FHMNGEGSLQPVPFPPDALVGVGIPRHARQ-----------INTLSHGEVVCAVTISNPTK--YV 459
            .|.:.......|    :|.:|.||..|:..           .|.:..|:.:|    .|..:  ||
  Fly   118 NHNSNSAGNNTV----EARLGGGISMHSMMNGGVVDQNGVATNQVLGGDRIC----FNFGRDLYV 174

  Fly   460 YTGGKGCVKVWDISQPGNK------NPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSI-- 516
            |: .:|..|..::|:|.:|      ||    .|  .|..|.|.  .|.|..|:||.....:.:
  Fly   175 YS-FRGAKKGTEMSKPIDKKFYKGTNP----SC--HDFNISSA--TPTGAPLLVGFTTGQIQLVS 230

  Fly   517 ---------------------------WDLASPTPRIKA-----------ELTSAAPA------- 536
                                       |...||...:.|           ||..||.|
  Fly   231 PHVGPREVRKLFNEERLIDKTKVTCLKWLPNSPHLFLAAHASGHLYLYNEELPCAATAPSYQPFK 295

  Fly   537 ------------------CYALAISPD----SKVCFSCC--------SDGNIAVWDLHNEILVRQ 571
                              .:....|.|    ::.|||.|        .||.:.|:......|:..
  Fly   296 LGDGYTILTSKSKTTRNPLFKWVFSTDNCCVNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGI 360

  Fly   572 FQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGR 609
            .:.:..|..|:..||||..:..||.|:.|..|.|.|.|
  Fly   361 ARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSLHERR 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	55/253 (22%)
		WD40 repeat	447..486	CDD:293791	12/46 (26%)
		WD40 repeat	494..532	CDD:293791	12/77 (16%)
		WD40 repeat	537..573	CDD:293791	10/47 (21%)
		WD40 repeat	580..615	CDD:293791	13/30 (43%)
		WD40 repeat	620..653	CDD:293791
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
CG6420	NP_001287545.1	WD40	<193..509	CDD:225201	44/214 (21%)
		WD40 repeat	208..249	CDD:293791	6/42 (14%)
		WD40 repeat	284..330	CDD:293791	5/45 (11%)
		WD40	<297..417	CDD:295369	24/102 (24%)
		WD40 repeat	369..404	CDD:293791	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910