DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and smu1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_989188.1	Gene:	smu1 / 394796	XenbaseID:	XB-GENE-971799	Length:	513	Species:	Xenopus tropicalis

Alignment Length:	340	Identity:	68/340 - (20%)
Similarity:	124/340 - (36%)	Gaps:	75/340 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 YDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEV 446
            :||.     ...|..|:....:.|.:..:.||.|:.| |....||:|..:.....| ..|..|.:
Frog   126 FDPR-----EAYPDGSSKEKRRAAIAQALAGEVSVVP-PSRLMALLGQALKWQQHQ-GLLPPGMI 183

  Fly   447 VCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEA 511
            :....           ||..||  |:.:......:|:.....:.:::...:..|||:.|:.|...
Frog   184 IDLFR-----------GKAAVK--DVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVD 235

  Fly   512 SNLSIWDLASPTPRIKAELTSAA--------PACYALAISPDSKVCFSCCSDGNIAVWDLHNEIL 568
            ..:.:|:..  |.:|:.:|...|        .|...:..|.|:::..:...||.|.||.:.:...
Frog   236 GFIEVWNFT--TGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQC 298

  Fly   569 VRQFQ-GHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWL 632
            :|:|: .|:.|.:|:..|.|.|::.:...|.|:|...|:.|:.|:
Frog   299 LRRFERAHSKGVTCLSFSKDCSQILSASFDQTIRVHGLKSGKTLK-------------------- 343

  Fly   633 AVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAW--RTPYGASIFQ 695
                                :...|.|.|....|...|.:.:|...|..:..|  :|...::.|
Frog   344 --------------------EFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTF- 387

  Fly   696 SKETSSVLSCDISTD 710
             |...|....||:.:
Frog   388 -KSLGSTAGTDITVN 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	53/280 (19%)
		WD40 repeat	447..486	CDD:293791	6/38 (16%)
		WD40 repeat	494..532	CDD:293791	9/37 (24%)
		WD40 repeat	537..573	CDD:293791	8/35 (23%)
		WD40 repeat	580..615	CDD:293791	10/34 (29%)
		WD40 repeat	620..653	CDD:293791	0/32 (0%)
		WD40 repeat	661..695	CDD:293791	7/35 (20%)
		WD40 repeat	702..726	CDD:293791	2/9 (22%)
smu1	NP_989188.1	Required for interaction with ik. /evidence=ECO:0000250\|UniProtKB:Q2TAY7	1..315		45/210 (21%)
		LisH_TPL	7..36	CDD:375350
		CTLH	40..90	CDD:128914
		Ge1_WD40	<158..>241	CDD:374606	18/96 (19%)
		WD40	205..512	CDD:238121	47/241 (20%)
		WD40 repeat	219..262	CDD:293791	10/44 (23%)
		WD40 repeat	268..305	CDD:293791	9/36 (25%)
		WD 3. /evidence=ECO:0000255	305..346		12/80 (15%)
		WD40 repeat	310..346	CDD:293791	10/75 (13%)
		WD 4. /evidence=ECO:0000255	347..386		9/38 (24%)
		WD40 repeat	353..393	CDD:293791	8/41 (20%)
		WD 5. /evidence=ECO:0000255	395..436		2/7 (29%)
		WD40 repeat	400..436	CDD:293791	0/2 (0%)
		WD 6. /evidence=ECO:0000255	440..479
		WD40 repeat	444..481	CDD:293791
		WD 7. /evidence=ECO:0000255	482..513
		WD40 repeat	487..511	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910