DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and tle5

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_956717.1	Gene:	tle5 / 393395	ZFINID:	ZDB-GENE-040426-1409	Length:	197	Species:	Danio rerio

Alignment Length:	243	Identity:	103/243 - (42%)
Similarity:	136/243 - (55%)	Gaps:	47/243 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |:|.. ||.|:     ...:|||.:|:.:|||:||.||||||||:||||:||::||:||||||:|
Zfish     2 MFPQS-RHSAS-----SQQLKFTTSDSCDRIKDEFQFLQAQYHSLKLECDKLASEKSEMQRHYIM 60

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:|||||.||.||||.:..|:||:|..:||||||.|:|||||||..|:|.||..|.|
Zfish    61 YYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTPPEMNSIIRQQLQ 125

  Fly   131 HGIQQLLQQIHAQQVPGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKPTGLEGP 195
               ...|.|:....:| ..|.|:|...|.|....|     ...||.:              |...
Zfish   126 ---AHQLSQLQGLALP-MTPLPLGLSQPAGLPAVT-----SSSGLFS--------------LSSI 167

  Fly   196 AAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDEKLQEDEGEKSD 243
            .|::.:|..                  |:.|.|...:..:|::|:|||
Zfish   168 LASQAQLAK------------------EDKSTRETSDSHREEDGDKSD 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	72/112 (64%)
		WD40	442..727	CDD:238121
		WD40 repeat	447..486	CDD:293791
		WD40 repeat	494..532	CDD:293791
		WD40 repeat	537..573	CDD:293791
		WD40 repeat	580..615	CDD:293791
		WD40 repeat	620..653	CDD:293791
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
tle5	NP_956717.1	TLE_N	8..129	CDD:397828	78/128 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3389
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810