DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Prp19

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_523783.1	Gene:	Prp19 / 37123	FlyBaseID:	FBgn0261119	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	72/305 - (23%)
Similarity:	122/305 - (40%)	Gaps:	43/305 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 NGIPHPSALTGG--KPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTIS 453
            |...|...||||  |.|..|:.:.|           .:|.: :..|.::|..:          |.
  Fly   231 NSADHSKILTGGNDKNATVFNKDTE-----------QMVAI-LKGHTKKITKV----------IY 273

  Fly   454 NPTK-YVYTGGKGC-VKVWDISQPGNKNPVSQLDCLQR--DNYIRSVKLLPDGRTLIVGGEASNL 514
            :|.: .|.||.... :::|.:       |.||...|.|  :..:..:.|.|.|..|:......:.
  Fly   274 HPNEDTVITGSPDMNIRIWHV-------PTSQTQLLLRCHEGPVTGLSLHPTGDYLLSTSSDKHW 331

  Fly   515 SIWDLASPTPRIKAELTSAAPACYALA-ISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDG 578
            :..|:.  |.|:..::...|......| ..||..:..:...|..:.:|||..:..|..|.|||..
  Fly   332 AFSDIR--TGRLLTKVIDTAEVGLTTAQFHPDGLIFGTGTVDSQVKIWDLKEQSNVANFPGHTGP 394

  Fly   579 ASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQ--QHDFSSQIFSLGYCPTGDWLAVGMENSHV 641
            .|.|..|.:|..|.|...|..|:.||||:.:..:  |.|...::..|.:..:|.:||:.  .|.|
  Fly   395 ISAISFSENGYYLATAADDACVKLWDLRKLKNFKTIQLDDGYEVKDLCFDQSGTYLAIA--GSDV 457

  Fly   642 EVLHASKPDKYQL-HLHESCVLSLRFAACGKWFVSTGKDNLLNAW 685
            .|....:..:.:: :.|.:....:||....::..||..|..|..:
  Fly   458 RVYLCKQWQELKVFNDHTALATGVRFGKHAQYLASTSMDRTLKLY 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	59/252 (23%)
		WD40 repeat	447..486	CDD:293791	9/40 (23%)
		WD40 repeat	494..532	CDD:293791	7/37 (19%)
		WD40 repeat	537..573	CDD:293791	8/36 (22%)
		WD40 repeat	580..615	CDD:293791	13/36 (36%)
		WD40 repeat	620..653	CDD:293791	7/32 (22%)
		WD40 repeat	661..695	CDD:293791	6/25 (24%)
		WD40 repeat	702..726	CDD:293791
Prp19	NP_523783.1	Ubox	2..68	CDD:128780
		Prp19	69..132	CDD:285771
		WD40	210..503	CDD:238121	72/305 (24%)
		WD40	<225..505	CDD:225201	72/305 (24%)
		WD40 repeat	269..305	CDD:293791	10/52 (19%)
		WD40 repeat	310..345	CDD:293791	7/36 (19%)
		WD40 repeat	354..389	CDD:293791	8/34 (24%)
		WD40 repeat	395..431	CDD:293791	12/35 (34%)
		WD40 repeat	438..484	CDD:293791	9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910