DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Tle1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006238343.1	Gene:	Tle1 / 362533	RGDID:	1309237	Length:	814	Species:	Rattus norvegicus

Alignment Length:	860	Identity:	488/860 - (56%)
Similarity:	562/860 - (65%)	Gaps:	176/860 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPS---PVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRH 62
            |:|.   |..|.|||     .|.||||.::|:||||||.||||||||:|||||||::||||||||
  Rat     1 MFPQSRHPTPHQAAG-----QPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60

  Fly    63 YVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGH 127
            ||||||||||||:||||||||||||||:..|::|||..:|||||.|||||||||||.|||.|||.
  Rat    61 YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGV 125

  Fly   128 QQQHGIQQLLQQIHAQQVP--GGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKPT 190
            :...|:....||:.||.:.  .|||.|:              .|| |.||  :|     |.|.|.
  Rat   126 RGLPGLPPTQQQLQAQHLSHGHGPPVPL--------------TPH-PSGL--QP-----PGIPPL 168

  Fly   191 G-------LEGPAAAEERL--RNSVSPADREKYRTRSP---------------------LDIEND 225
            |       |....:.:..|  ::.....|.|::|.|.|                     .:..:|
  Rat   169 GGSASLLALSSALSGQSHLAIKDDKKHHDAERHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSSD 233

  Fly   226 SKRRK--DEKLQEDEGEKSDQDLVVDVANEMES-------HSPRPNGEHVSMEVRDRESLNGERL 281
            .|:||  |:...:.:|:|||.:|||||:||..|       ||||.||            ::..||
  Rat   234 IKKRKVDDKDNYDSDGDKSDDNLVVDVSNEDPSSPHASPTHSPRENG------------IDKNRL 286

  Fly   282 EKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVN---- 339
            .|..:||       |.:.::||.|:.|||:|::   ||..||..|:.||||.:..|.||.:
  Rat   287 LKKDASG-------SPASTASSGSSSSLKSKEVNLHEKANTPVLKSSTPTPRSDMPTPGTSATPG 344

  Fly   340 -------PKQMMP-------------------------------------------------QGP 348
                   |..|.|                                                 .||
  Rat   345 LRPGLGKPPAMEPLVNQAGFGFHLELVPGSGKFGLKEKSWILSRKSSFEIKSAAGLRTPLAVPGP 409

  Fly   349 PPAGY--------------PGAPY--------QRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTN 391
            .||.:              |||.|        |..|.......:..||||.|.:.:||..|:|..
  Rat   410 YPAPFGMVPHAGMNGELTSPGAAYAGLHSMSPQMSAAAAAAAAAVVAYGRSPMVGFDPPPHMRVP 474

  Fly   392 GI-PHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNP 455
            .| |:.:.:.|||||||||:..:|.:||||||||||:|.||||||||||||:|||||||||||||
  Rat   475 SIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNP 539

  Fly   456 TKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLA 520
            |::|||||||||||||||.||||:||||||||.|||||||.||||||.|||||||||.|||||||
  Rat   540 TRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLA 604

  Fly   521 SPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDIS 585
            :|||||||||||:||||||||||||||||||||||||||||||||:.||||||||||||||||||
  Rat   605 APTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS 669

  Fly   586 PDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPD 650
            .||::||||||||||||||||||||||||||:||||||||||||:|||||||:|:|||||.:|||
  Rat   670 NDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD 734

  Fly   651 KYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIV 715
            ||||||||||||||:||.||||||||||||||||||||||||||||||:|||||||||.||||||
  Rat   735 KYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIV 799

  Fly   716 TGSGDKKATVYEVIY 730
            |||||||||||||||
  Rat   800 TGSGDKKATVYEVIY 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	86/112 (77%)
		WD40	442..727	CDD:238121	258/284 (91%)
		WD40 repeat	447..486	CDD:293791	34/38 (89%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	33/35 (94%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	27/32 (84%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
Tle1	XP_006238343.1	TLE_N	9..143	CDD:397828	96/138 (70%)
		WD40	527..811	CDD:238121	258/283 (91%)
		WD40 repeat	531..570	CDD:293791	34/38 (89%)
		WD40 repeat	578..616	CDD:293791	33/37 (89%)
		WD40 repeat	621..657	CDD:293791	33/35 (94%)
		WD40 repeat	664..699	CDD:293791	31/34 (91%)
		WD40 repeat	704..737	CDD:293791	27/32 (84%)
		WD40 repeat	745..779	CDD:293791	31/33 (94%)
		WD40 repeat	786..810	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2083
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	888	1.000	Inparanoid score	I373
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm63535
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880