DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and Wdr5

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001034123.1 Gene:Wdr5 / 362093 RGDID:1305159 Length:334 Species:Rattus norvegicus


Alignment Length:382 Identity:75/382 - (19%)
Similarity:137/382 - (35%) Gaps:82/382 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   366 QRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVG 430
            ::|.::.|..:|.|                .|:.|..||.            ||.          
  Rat     6 KKPETEAARAQPTP----------------SSSATQSKPT------------PVK---------- 32

  Fly   431 IPRHARQINTLSHGEVVCAVTIS-NPTKYVYTGGKGCVKVW-------DISQPGNKNPVSQLDCL 487
             |.:|.:.....|.:.|.:|..| |......:.....:|:|       :.:..|:|..:|     
  Rat    33 -PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS----- 91

  Fly   488 QRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSC 552
                   .|....|...|:...:...|.|||::|  .:....|...:...:....:|.|.:..|.
  Rat    92 -------DVAWSSDSNLLVSASDDKTLKIWDVSS--GKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147

  Fly   553 CSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ--HD 615
            ..|.::.:||:.....::....|:|..|.:..:.|||.:.:...|...|.||...|:.|:.  .|
  Rat   148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212

  Fly   616 FSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKP---DKYQLHLHES-CVLSLRFAACGKWFVST 676
            .:..:..:.:.|.|.::.....::.:::...||.   ..|..|.:|. |:.:......|||.||.
  Rat   213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277

  Fly   677 GKDNLLNAWRTPYGASIFQSKE--------TSSVLSCDISTDDKYIVTGSGDKKATV 725
            .:|||:..|.       .|:||        |..|:|......:..|.:.:.:...|:
  Rat   278 SEDNLVYIWN-------LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 63/306 (21%)
WD40 repeat 447..486 CDD:293791 9/46 (20%)
WD40 repeat 494..532 CDD:293791 9/37 (24%)
WD40 repeat 537..573 CDD:293791 6/35 (17%)
WD40 repeat 580..615 CDD:293791 10/36 (28%)
WD40 repeat 620..653 CDD:293791 4/35 (11%)
WD40 repeat 661..695 CDD:293791 9/33 (27%)
WD40 repeat 702..726 CDD:293791 4/24 (17%)
Wdr5NP_001034123.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 8/52 (15%)
WD40 37..331 CDD:238121 63/312 (20%)
WD 1 43..82 7/38 (18%)
WD40 repeat 48..85 CDD:293791 6/36 (17%)
WD 2 85..126 11/54 (20%)
WD40 repeat 91..127 CDD:293791 10/49 (20%)
WD 3 128..168 6/39 (15%)
WD40 repeat 132..168 CDD:293791 6/35 (17%)
WD 4 169..208 12/38 (32%)
WD40 repeat 175..210 CDD:293791 10/34 (29%)
WD 5 212..253 5/40 (13%)
WD40 repeat 217..253 CDD:293791 4/35 (11%)
WD 6 256..296 14/46 (30%)
WD40 repeat 261..298 CDD:293791 13/43 (30%)
WD 7 299..333 5/29 (17%)
WD40 repeat 304..330 CDD:293791 4/24 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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