DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and taf5l

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_956146.1 Gene:taf5l / 334055 ZFINID:ZDB-GENE-030131-5987 Length:601 Species:Danio rerio


Alignment Length:406 Identity:82/406 - (20%)
Similarity:135/406 - (33%) Gaps:138/406 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   450 VTISNPTKY-VYTGGKG-------CVKVW---DISQ-----------PGNKNPVSQL-DCLQR-- 489
            ||.:..|.| :|..|.|       ....|   |.|:           |.|:..:..| ||::|  
Zfish   198 VTAAQRTDYQLYGAGVGTGNTSSSSSSTWASVDGSEGAERLEVPAGLPQNEAALENLQDCIKRVR 262

  Fly   490 -----------------DNYIRSVKLLPDGRTLIVGGEASNLSIWDL------ASPTPRIKAELT 531
                             :..:.:.::..|.|.|..|.:.|.:.:|.|      |.|.   ||:::
Zfish   263 EGPPSLTTVCFYAFQHTEQLLNTAEVSADSRLLAAGFDNSAVKLWSLRARKLKAGPH---KADVS 324

  Fly   532 SAAPAC---------------------------YALAISPDSKVCFSCCSDGNIAVWDLH---NE 566
            ....||                           |..|...|:....||..|..:..|||.   |.
Zfish   325 KIRLACDVLEEEADDEDASGSEIKTLRGHSGPVYRTAFLTDASGLLSCSEDSTVRYWDLKSFTNT 389

  Fly   567 IL---------------------------------------VRQFQGHTDGASCIDISPDGSRLW 592
            :|                                       :|.:.||.....|:...|:.:.:.
Zfish   390 VLYRGHAYPVWDVDVSPCSLYFSTASHDRTARLWSFARTYPLRLYAGHLSDVDCVKFHPNSNYIA 454

  Fly   593 TGGLDNTVRSWDLREG---RQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQ- 653
            ||..|.|||.|..|:|   |....|  ...:.:|.:.|.|.:||...|:..:::...:....:: 
Zfish   455 TGSTDKTVRLWSTRQGASVRLFTGH--RGPVLTLAFSPNGKYLASAGEDQRLKLWDLASGGLFKD 517

  Fly   654 LHLHESCVLSLRFAACGKWFVSTGKDNLLNAW--RTPYGAS---------IFQ-SKETSSVLSCD 706
            |..|...:.||.|:.......|...||.:..|  |..:|::         |.| :..||::|:..
Zfish   518 LRGHTDTISSLSFSQDSSLVASASMDNTVRVWDIRNAHGSAPTDGCSSELIGQYTGSTSNILNVQ 582

  Fly   707 ISTDDKYIVTGSGDKK 722
            ....:..:|||:..:|
Zfish   583 FMACNLLLVTGTAMEK 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 82/406 (20%)
WD40 repeat 447..486 CDD:293791 13/58 (22%)
WD40 repeat 494..532 CDD:293791 11/43 (26%)
WD40 repeat 537..573 CDD:293791 13/104 (13%)
WD40 repeat 580..615 CDD:293791 12/37 (32%)
WD40 repeat 620..653 CDD:293791 6/32 (19%)
WD40 repeat 661..695 CDD:293791 10/44 (23%)
WD40 repeat 702..726 CDD:293791 5/21 (24%)
taf5lNP_956146.1 TAF5_NTD2 66..200 CDD:176269 1/1 (100%)
WD40 <227..581 CDD:225201 70/358 (20%)
WD40 289..593 CDD:238121 63/308 (20%)
WD40 repeat 357..394 CDD:293791 11/36 (31%)
WD40 repeat 400..436 CDD:293791 1/35 (3%)
WD40 repeat 441..477 CDD:293791 12/35 (34%)
WD40 repeat 484..519 CDD:293791 6/34 (18%)
WD40 repeat 525..572 CDD:293791 11/46 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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