DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and ebi

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_477329.1	Gene:	ebi / 33212	FlyBaseID:	FBgn0263933	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	144/758 - (18%)
Similarity:	243/758 - (32%)	Gaps:	216/758 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 VMYYEMSYGLNVEMHKQTEIAKRLN--TLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIG 126
            ::|.|:.:.:.    :..|:|:.:.  :||:.::|            .|:..|.:...|
  Fly    57 LLYTEVEWSVG----EDGEVARPIEGLSLIDAVMP------------EVKPLKPIVKTE------ 99

  Fly   127 HQQQHGIQQLLQQIHAQQVPGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIK--- 188
                               ||.|    ||::.....|....             .:.:|:||
  Fly   100 -------------------PGKP----GAVDSSAPAGGNQN-------------NNAKPEIKIEP 128

  Fly   189 PTGLEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDEKLQEDEGEKSDQDLVVDVANE 253
            .||:.| :|...::..|.:.......::.|.:|...::..........:.|...:|   ......
  Fly   129 GTGVAG-SAGGNKIAGSTTGTSTPTDQSASEVDSSGNAANNAGGTYAGNNGAGGNQ---ASTGGS 189

  Fly   254 MESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRST--PSLKTKDMEK 316
            ..:.:| ..|:..:.....::|.|.......||.........|...::||.||  .|..:..:|:
  Fly   190 NSTSTP-AGGDLAAPGASQKKSQNSNEAGSSSSGNAGNANATSTDDAASSTSTNGNSSTSSSVEQ 253

  Fly   317 PG---TP-GAKARTPTPNAA------------APAPGVNPKQMMPQGPPPAGYPGAPYQRPADPY 365
            |.   || |....|..|:||            ||:..|..:.........:|...|....|:...
  Fly   254 PTSGLTPAGGTVSTSNPDAAASGGASTATGSKAPSGAVTIRVGAQGNNVQSGSSNAQSSAPSGTI 318

  Fly   366 QRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVG 430
            ....|                    .|...|:||.                     |.|....:.
  Fly   319 SSSTS--------------------GGAGTPAALV---------------------PMDIDENIE 342

  Fly   431 IPRHARQINTLSHGEV-VCAVTISNPTKYVYTGGKG--CVKVWDISQPG-NKNPVSQLDCLQR-- 489
            ||....::......|| :||   .||::.:...|.|  ..::||:|... |.|.:....|:|:
  Fly   343 IPESKARVLRGHESEVFICA---WNPSRDLLASGSGDSTARIWDMSDANTNSNQLVLRHCIQKGG 404

  Fly   490 --------------------------DNYIRSVKLLPDGRT----------------------LI 506
                                      |.|.|..|  .|||.                      ::
  Fly   405 AEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWK--TDGRLASTLGQHKGPIFALKWNKCGNYIL 467

  Fly   507 VGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCF-SCCSDGNIAVWDLHNEILVR 570
            ..|......||| ||.....:.....:||   ||.:...:...| ||.:|..|.|..|.....::
  Fly   468 SAGVDKTTIIWD-ASTGQCTQQFAFHSAP---ALDVDWQTNQAFASCSTDQRIHVCRLGVNEPIK 528

  Fly   571 QFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGR---QLQQHDFSSQIFSLGYCPTGDWL 632
            .|:|||:..:.|...|.|..|.:...|.|::.|.:...|   .||.|  |.:|:::.:.|||.
  Fly   529 TFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSMNRDRCCHDLQAH--SKEIYTIKWSPTGP-- 589

  Fly   633 AVGMENSHVEVLHASKPDKYQLHL--------------HESCVLSLRFAACGKWFVSTGKDNLLN 683
              |..|.:..::.||......:.|              |...|.|:.|:..||...|...|..::
  Fly   590 --GTNNPNTNLILASASFDSTVRLWDVERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSFDKCVH 652

  Fly   684 AWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVY 726
            .|.|..|..:...|.|..:.  ::..:.|....|:.....:|:
  Fly   653 IWSTQTGQLVHSYKGTGGIF--EVCWNSKGTKVGASASDGSVF 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	10/61 (16%)
		WD40	442..727	CDD:238121	80/357 (22%)
		WD40 repeat	447..486	CDD:293791	11/41 (27%)
		WD40 repeat	494..532	CDD:293791	11/59 (19%)
		WD40 repeat	537..573	CDD:293791	9/36 (25%)
		WD40 repeat	580..615	CDD:293791	10/37 (27%)
		WD40 repeat	620..653	CDD:293791	8/32 (25%)
		WD40 repeat	661..695	CDD:293791	10/33 (30%)
		WD40 repeat	702..726	CDD:293791	2/23 (9%)
ebi	NP_477329.1	LisH	6..32	CDD:285685
		WD40	349..655	CDD:238121	72/320 (23%)
		WD40 repeat	358..402	CDD:293791	13/46 (28%)
		WD40 repeat	414..449	CDD:293791	7/36 (19%)
		WD40 repeat	454..490	CDD:293791	6/36 (17%)
		eIF2A	457..665	CDD:285825	53/217 (24%)
		WD40 repeat	497..531	CDD:293791	8/33 (24%)
		WD40 repeat	537..573	CDD:293791	8/35 (23%)
		WD40 repeat	579..624	CDD:293791	9/48 (19%)
		WD40 repeat	630..654	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910