DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and prpf4

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_956049.1	Gene:	prpf4 / 326944	ZFINID:	ZDB-GENE-030131-5143	Length:	507	Species:	Danio rerio

Alignment Length:	297	Identity:	74/297 - (24%)
Similarity:	120/297 - (40%)	Gaps:	53/297 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 NPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGG--------- 509
            |....|.....|..|:|.:.           ||    ..||:::    |....||.
Zfish   227 NSKLLVTASWSGLCKLWKVP-----------DC----TLIRTLR----GHNTNVGAISFHPQATL 272

  Fly   510 --EASNLS-----------IWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVW 561
              |.|:::           :|.|.|..|  .|::...:.....:...|..:...:.|.|.:..:|
Zfish   273 TLEESDVNMASCAADGSVKLWSLDSDEP--IADIEGHSMRVARVTWHPSGRFLGTTCYDHSWRLW 335

  Fly   562 DLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGR---QLQQHDFSSQIFSL 623
            ||..:..:...:||:.|...:...||||...|||||:..|.||||.||   .|:.|  ..:|:|:
Zfish   336 DLEVQEEILHQEGHSKGVHDLHFHPDGSLAGTGGLDSFARVWDLRTGRCVMFLEGH--IKEIYSI 398

  Fly   624 GYCPTGDWLAVGMENSHVEVLH-ASKPDKYQLHLHESCVLSLRFAACGKWFVSTGK-DNLLNAWR 686
            .:.|.|..:|.|..::..:|.. ..:...|.:..|::.|.|::|......::.||. ||....|.
Zfish   399 NFSPNGFHVATGSGDNACKVWDLRQRRCIYTIPAHQNLVSSVKFQPNDGHYLLTGAYDNTAKIWT 463

  Fly   687 TPYGASIFQ--SKETSSVLSCDISTDDKYIVTGSGDK 721
            .| |.|..:  :.....|:..|:|.|.:.|.|.|.|:
Zfish   464 HP-GWSPLKTLAGHEGKVMGVDLSPDGQLIATCSYDR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	74/297 (25%)
		WD40 repeat	447..486	CDD:293791	5/31 (16%)
		WD40 repeat	494..532	CDD:293791	11/59 (19%)
		WD40 repeat	537..573	CDD:293791	6/35 (17%)
		WD40 repeat	580..615	CDD:293791	17/37 (46%)
		WD40 repeat	620..653	CDD:293791	7/33 (21%)
		WD40 repeat	661..695	CDD:293791	11/34 (32%)
		WD40 repeat	702..726	CDD:293791	8/20 (40%)
prpf4	NP_956049.1	SFM	88..124	CDD:128776
		WD40	<192..504	CDD:225201	74/297 (25%)
		WD40	218..504	CDD:238121	74/297 (25%)
		WD40 repeat	219..256	CDD:293791	9/47 (19%)
		WD40 repeat	262..306	CDD:293791	8/45 (18%)
		WD40 repeat	311..347	CDD:293791	6/35 (17%)
		WD40 repeat	354..389	CDD:293791	16/34 (47%)
		WD40 repeat	395..429	CDD:293791	7/33 (21%)
		WD40 repeat	437..474	CDD:293791	11/37 (30%)
		WD40 repeat	480..504	CDD:293791	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910