DRSC/TRiP Functional Genomics Resources

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Protein Alignment gro and tle3a

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001300623.1 Gene:tle3a / 30206 ZFINID:ZDB-GENE-990415-86 Length:762 Species:Danio rerio


Alignment Length:802 Identity:487/802 - (60%)
Similarity:559/802 - (69%) Gaps:112/802 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||.. ||||...|...| .|||:|::.:|||:||.||||||||:|:|.:||:||||||||||||
Zfish     1 MYPQG-RHPAPHQPGQPG-FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVM 63

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:|||||||||||||.::.|::|||..:|||||.|||||||||||.|||.|||.:..
Zfish    64 YYEMSYGLNIEMHKQTEIAKRLNAILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGL 128

  Fly   131 HGI---QQLLQQIHAQQVPGG----PPQPMGALNPFG------------ALGATMGLPHGPQGLL 176
            ..:   ||.||..|......|    ||.|.| |.|.|            ||||....||.|   :
Zfish   129 PNLPLTQQQLQAQHLSHAAHGPVALPPHPSG-LQPPGIPPVTGSGSGLLALGALGSQPHLP---V 189

  Fly   177 NKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPAD-----REKYRTRSPLDIENDSKRRKDE---- 232
            .....||  |::         ..|...||:||:|     .||:|..|  |...|||:||.|    
Zfish   190 KDEKNHH--DLE---------HRESTNNSISPSDSLRTTSEKHRGSS--DYSLDSKKRKVEDKDS 241

  Fly   233 -KLQEDEGEKSDQDLVVDVANE-------MESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGI 289
             ...:.:|:||| ||||||:||       ..:|||..||                 ::||..:  
Zfish   242 MSRYDSDGDKSD-DLVVDVSNEDPATPRGSPAHSPPENG-----------------IDKPRPA-- 286

  Fly   290 KQERPPSRSGSSSSRSTPSLKTKD---MEKPGTPGAKARTPTPNAAAPAPGVN--PKQMMPQGPP 349
            |::.|.|.:..:||.||||.|.|:   .:|..|||.|:.||||...||.||.:  |......|.|
Zfish   287 KKDTPNSPASVASSGSTPSSKNKEHGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRPILGKP 351

  Fly   350 PAGYPGAPYQRPADPYQRP------------------------------PSDPAYGRPPPMPYDP 384
            |.....||..|....|..|                              .:..||||.|...:: 
Zfish   352 PMEALAAPALRTPLTYPTPFAMMSHHEMNGSLTNPGVYAGLHISPQMSAAAAAAYGRSPMAGFE- 415

  Fly   385 HAHVRTNGIPHP-SALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVC 448
            |.|:|..|:|.. ::::|||||||||::.:|.:||||||||||:|.|||||||||||||||||||
Zfish   416 HPHMRAPGLPASLTSISGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLSHGEVVC 480

  Fly   449 AVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASN 513
            ||||||||::||||||||||:|||||||:|:||||||||.|||||||.||||||||||||||||.
Zfish   481 AVTISNPTRHVYTGGKGCVKIWDISQPGSKSPVSQLDCLNRDNYIRSCKLLPDGRTLIVGGEAST 545

  Fly   514 LSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDG 578
            |:||||||.||||||||||:||||||||||||:|||||||||||||||||||:.|||||||||||
Zfish   546 LTIWDLASQTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDG 610

  Fly   579 ASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEV 643
            |||||||.||::||||||||||||||||||||||||||:||||||||||||:|||||||:|:|||
Zfish   611 ASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV 675

  Fly   644 LHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDIS 708
            ||.:|||||||||||||||||:||.||||||||||||||||||||||||||||||:|||||||||
Zfish   676 LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS 740

  Fly   709 TDDKYIVTGSGDKKATVYEVIY 730
            .|||||||||||||||||||||
Zfish   741 ADDKYIVTGSGDKKATVYEVIY 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828 80/112 (71%)
WD40 442..727 CDD:238121 257/284 (90%)
WD40 repeat 447..486 CDD:293791 33/38 (87%)
WD40 repeat 494..532 CDD:293791 33/37 (89%)
WD40 repeat 537..573 CDD:293791 32/35 (91%)
WD40 repeat 580..615 CDD:293791 31/34 (91%)
WD40 repeat 620..653 CDD:293791 27/32 (84%)
WD40 repeat 661..695 CDD:293791 31/33 (94%)
WD40 repeat 702..726 CDD:293791 22/23 (96%)
tle3aNP_001300623.1 TLE_N 1..143 CDD:281857 94/143 (66%)
DUF4674 <290..>335 CDD:292347 20/44 (45%)
WD40 <468..760 CDD:225201 264/291 (91%)
WD40 474..759 CDD:238121 257/284 (90%)
WD40 repeat 479..518 CDD:293791 33/38 (87%)
WD40 repeat 526..564 CDD:293791 33/37 (89%)
WD40 repeat 569..605 CDD:293791 32/35 (91%)
WD40 repeat 612..647 CDD:293791 31/34 (91%)
WD40 repeat 652..685 CDD:293791 27/32 (84%)
WD40 repeat 693..727 CDD:293791 31/33 (94%)
WD40 repeat 734..758 CDD:293791 22/23 (96%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 249 1.000 Domainoid score I2087
eggNOG 1 0.900 - - E1_KOG0639
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H137876
Inparanoid 1 1.050 878 1.000 Inparanoid score I384
OMA 1 1.010 - - QHG48578
OrthoDB 1 1.010 - - D251248at33208
OrthoFinder 1 1.000 - - FOG0000904
OrthoInspector 1 1.000 - - otm25426
orthoMCL 1 0.900 - - OOG6_101214
Panther 1 1.100 - - O PTHR10814
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4593
SonicParanoid 1 1.000 - - X487
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1616.370

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