DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Tle2

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_038934581.1	Gene:	Tle2 / 299636	RGDID:	1306665	Length:	766	Species:	Rattus norvegicus

Alignment Length:	824	Identity:	440/824 - (53%)
Similarity:	524/824 - (63%)	Gaps:	152/824 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQG-PIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYV 64
            |||.. |||.   |...| |.||::.:..:||||||.||||||||:|||||||::||||||||||
  Rat     1 MYPQG-RHPT---PLQSGQPFKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 61

  Fly    65 M-----------------------YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQV 106
            |                       |||||||||:|||||.||.|||:.:..|::|||..:|||||
  Rat    62 MAAPHQCPQGGTSCPHWPRLSPLQYYEMSYGLNIEMHKQAEIVKRLSAICAQMVPFLTQEHQQQV 126

  Fly   107 LQAVERAKQVTMQELNLIIGHQQQHGIQQLLQQI-HAQQVPGGPPQPMGALNPFGALGATMGLPH 170
            ||||:||||||:.|||.::|.|.|      ||.: ||..||..|       .|.|.:||
  Rat   127 LQAVDRAKQVTVGELNNLLGQQNQ------LQPLSHAPPVPLTP-------RPAGLVGA------ 172

  Fly   171 GPQGLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSV-----------SPADREKYRTRSP----- 219
            |..|||              .|.|..||:.:|..:|           |..||...|:.||
  Rat   173 GATGLL--------------ALSGALAAQAQLVAAVKEDRVGVDTEGSRVDRAASRSSSPSPPES 223

  Fly   220 -LDIENDSKRRKDEKLQ-----------EDEGEKSDQDLVVDVANEMESHSP--RPNGEHVSMEV 270
             .:.|:.|.|..:.|.|           :.|.:|||.:||||.....|..||  .|.|
  Rat   224 LAEEEHPSSRDSNGKQQRAEDKNMSGPYDSEEDKSDYNLVVDEDQPSEPPSPATTPCG------- 281

  Fly   271 RDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDME----KPGTPGAKARTPTPNA 331
                       :.|.....:::...|.:..:||..:|..::||:.    ..|||.:.:..|:|..
  Rat   282 -----------KAPLCIPARRDLTDSPASLASSLGSPLPRSKDLALNDLSTGTPASGSCGPSPPQ 335

  Fly   332 AAPAPGVNPK----QMMPQGPPPA-------------------------------GYPGAPYQRP 361
            .:..||.:..    |:..|..||.                               ..||:.....
  Rat   336 DSSTPGPSSASHLCQLATQPAPPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYVSLH 400

  Fly   362 ADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDAL 426
            ..|  :..|...||..|.|.::.|.|:|.:.|..|| :.|.|||||||::.:|.:||||||.|||
  Rat   401 LSP--QVSSSVVYGCSPLMAFESHPHLRGSSISLPS-IPGAKPAYSFHVSADGQMQPVPFPSDAL 462

  Fly   427 VGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDN 491
            ||.||||||||::||:|||||||||||:.|::|||||||||||||:.|||:|.||:|||||.|||
  Rat   463 VGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGKGCVKVWDVGQPGSKTPVAQLDCLNRDN 527

  Fly   492 YIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDG 556
            ||||.||||||::||||||||.|||||||:|||||||||||:||||||||||||:||||||||||
  Rat   528 YIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDG 592

  Fly   557 NIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIF 621
            ||.||||.|:.:|||||||||||||||||..|:||||||||||||.|||||||||||||||||||
  Rat   593 NIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 657

  Fly   622 SLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWR 686
            |||:||:.||||||||:|||||||..||:||||.|||||||||:||:||:|||||||||||||||
  Rat   658 SLGHCPSQDWLAVGMESSHVEVLHVRKPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWR 722

  Fly   687 TPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            ||||||||||||:|||||||||.::|||||||||||||||||:|
  Rat   723 TPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	78/136 (57%)
		WD40	442..727	CDD:238121	242/284 (85%)
		WD40 repeat	447..486	CDD:293791	29/38 (76%)
		WD40 repeat	494..532	CDD:293791	32/37 (86%)
		WD40 repeat	537..573	CDD:293791	29/35 (83%)
		WD40 repeat	580..615	CDD:293791	30/34 (88%)
		WD40 repeat	620..653	CDD:293791	25/32 (78%)
		WD40 repeat	661..695	CDD:293791	30/33 (91%)
		WD40 repeat	702..726	CDD:293791	20/23 (87%)
Tle2	XP_038934581.1	TLE_N	10..152	CDD:397828	81/147 (55%)
		PHA03247	<269..458	CDD:223021	50/209 (24%)
		WD40	479..763	CDD:421866	242/283 (86%)
		WD40 repeat	483..522	CDD:293791	29/38 (76%)
		WD40 repeat	530..568	CDD:293791	32/37 (86%)
		WD40 repeat	573..609	CDD:293791	29/35 (83%)
		WD40 repeat	616..651	CDD:293791	30/34 (88%)
		WD40 repeat	656..691	CDD:293791	27/34 (79%)
		WD40 repeat	697..731	CDD:293791	30/33 (91%)
		WD40 repeat	738..762	CDD:293791	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3169
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm63535
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.820