DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Wdr88

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006228961.2	Gene:	Wdr88 / 292809	RGDID:	1560122	Length:	961	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	112/581 - (19%)
Similarity:	195/581 - (33%)	Gaps:	144/581 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 DIKPTGLEGPAAAEERLRNSVSPADREKYRT---RSPLDIENDSKRRKDEKLQEDEGEKSDQDLV 247
            |.|.:.::...::.:..|.|:   |..|:..   |.|:|.:.||   .|.|....:.::...|
  Rat   415 DSKRSSVDSKRSSVDSKRGSI---DSRKFSVDSKRDPVDNKRDS---VDSKRFSVDSKRFSVD-- 471

  Fly   248 VDVANEMESHSPRPNGEHVSMEVRDRESLNGERL---EKPSSSGIKQERPPSRSGSSSSRSTPSL 309
                           ...||:..: |.|::.:|.   .:.||.|...:....|..|...|...||
  Rat   472 ---------------SRRVSISSK-RSSIDSKRSSVDSRKSSGGTLLDFSEDRRSSGEDRDISSL 520

  Fly   310 KTKDMEKPGTPGAKARTPTPNAAAPAPGVNPKQMMPQGPPPAGYPGAPYQRPADPYQRPPSDPAY 374
            ..  :.....|.|.............|.:.....:....|.|  ....:..|.:.:.:.....::
  Rat   521 AR--VRHSRVPWATLMRALGRFKLYLPHIRRYYNLSSRDPLA--LDKDFLLPREKHLKATVQKSW 581

  Fly   375 GRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYS---FHMNG------------------EGSL-- 416
            |...|:...|:           ..|||.....|   |.|:.                  :|::
  Rat   582 GNQQPLSKIPY-----------KTLTGHDQTVSSCHFCMDDTRLLSSSYDCTVKLWDAEDGTVIC 635

  Fly   417 --QPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKN 479
              :|.|..|                     .:.|::|..| .:.|.:.....|:.||: :.|
  Rat   636 DFEPRPKAP---------------------VLECSITADN-RRIVASSYDKTVRAWDV-ETG--- 674

  Fly   480 PVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEAS-NLSIWDLASPTP--RIKAELTSAAPACYALA 541
              ..|..::.|.::...|..|:|:.::...:.: .:.:.|..:.|.  .:||:...:..:|   .
  Rat   675 --QLLWKVRHDTFVVCCKFSPNGKYVLSALDVNRGIYLMDPENITSVIHMKAQHQRSITSC---C 734

  Fly   542 ISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQ-GHTDGAS--CIDISPDGSRLWTGGLDNTVRSW 603
            ..|||:...|...|.:|.:||:.:...:...| .||:..|  |...|  |..|.|...|.|::.|
  Rat   735 FDPDSQKVASVSMDKSIKIWDVTSRATLFTIQEAHTNAISDCCFTFS--GHFLCTSSWDRTIKIW 797

  Fly   604 DLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAA 668
            ::..|      :|.:|    |.|.|   |..|                     ||.||.|...|.
  Rat   798 NVHTG------EFRNQ----GACVT---LMKG---------------------HEGCVSSCCIAR 828

  Fly   669 CGKWFVSTGKDNLLNAWRTPYGASIFQSK-ETSSVLSCDISTDDKYIVTGSGDKKATVYEV 728
            ...:.:|.|.|..:..|....|......| ....|....||.|.|:|::.|.|....::.:
  Rat   829 DSSFLISGGFDKTVAIWDVGGGYRKLSLKGHEDWVTDVAISNDKKWILSASKDNSMRLWNI 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	66/291 (23%)
		WD40 repeat	447..486	CDD:293791	9/38 (24%)
		WD40 repeat	494..532	CDD:293791	7/40 (18%)
		WD40 repeat	537..573	CDD:293791	9/35 (26%)
		WD40 repeat	580..615	CDD:293791	10/36 (28%)
		WD40 repeat	620..653	CDD:293791	5/32 (16%)
		WD40 repeat	661..695	CDD:293791	8/33 (24%)
		WD40 repeat	702..726	CDD:293791	8/23 (35%)
Wdr88	XP_006228961.2	MCP_signal	<33..134	CDD:304920
		MA	48..274	CDD:214599
		MCP_signal	<139..239	CDD:304920
		WD40	458..903	CDD:225201	100/532 (19%)
		WD40	591..888	CDD:238121	77/374 (21%)
		WD40 repeat	602..640	CDD:293791	4/37 (11%)
		WD40 repeat	646..681	CDD:293791	9/41 (22%)
		WD40 repeat	686..723	CDD:293791	5/36 (14%)
		WD40 repeat	731..766	CDD:293791	9/37 (24%)
		WD40 repeat	773..815	CDD:293791	16/56 (29%)
		WD40 repeat	821..847	CDD:293791	7/25 (28%)
		WD40 repeat	863..887	CDD:293791	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910