DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and Rptor

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001127971.2 Gene:Rptor / 287871 RGDID:1311784 Length:1335 Species:Rattus norvegicus


Alignment Length:579 Identity:101/579 - (17%)
Similarity:169/579 - (29%) Gaps:249/579 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 DLVVDVANEM---ESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQER----PPSRSGSSS 302
            ||.:.|.|.:   .:.:.||      ..:.|..||.......|::.|:...:    ||:.|.||.
  Rat   828 DLAMKVLNSIAYKATVNARP------QRILDTSSLTQSAPASPTNKGMHIHQVGGSPPASSTSSC 886

  Fly   303 SRSTPSLK---TKDM--EKPGTPGAKARTPTPNA-AAPAPGVNPKQMMPQGP--------PPAGY 353
            |.:....|   ::|:  .:|||.|......||:: ..|    ..::|..:||        ..||:
  Rat   887 SLTNDVAKQTVSRDLPSSRPGTAGPTGAQYTPHSHQFP----RTRKMFDKGPDQTTDDADDAAGH 947

  Fly   354 PG---APYQRP---------ADPYQRPPSDPAYGRPPPMPYDPHAHVRTN--------------- 391
            ..   |..|..         |.|..:.|.:          :|..:.:|..               
  Rat   948 KSFICATMQTGFCDWSARYFAQPVMKIPEE----------HDLESQIRKEREWRFLRNTRVRKQA 1002

  Fly   392 ---------------------GIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVG------- 428
                                 |:|         ....||          ||.|...|.       
  Rat  1003 QQVIQKGITRLDDQIFLNRNPGVP---------SVVKFH----------PFTPCIAVADKDSICF 1048

  Fly   429 -------------VGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGC-----------VKV 469
                         .|.||:.|                  .|...|..|:.|           ::|
  Rat  1049 WDWEKGEKLDYFHNGNPRYTR------------------VTAMEYLNGQDCSLLLTATDDGAIRV 1095

  Fly   470 WDISQPGNKNP--VSQLDCLQRDNYIRSVKLLPDGR-------------TLIVGGEASNLSIWDL 519
            |.......|||  |:....|.        .:||..|             .|:..|:...:.|||.
  Rat  1096 WKNFADLEKNPEMVTAWQGLS--------DMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDT 1152

  Fly   520 ASPTPRIKAELTSAAPACYALAISPDS--KVCFSCCSDGNIAVWDLH---NEILVRQFQGHT--- 576
            ...| ::: ::.:.|.:| ..::|.||  .:..:...||:|.|:|..   :|..|..::.||   
  Rat  1153 DRET-KVQ-DIPTGADSC-VTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWV 1214

  Fly   577 ---------------------------------------DGASCIDISPDGSRLWTGGLD----- 597
                                                   .|.:.:||.|..:.:..|.::     
  Rat  1215 VKAYLQKHPEGHIVSVSVNGDVRFFDPRMPESVNVMQIVKGLTALDIHPQANLIACGSMNQFTAI 1279

  Fly   598 --------NTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASK 648
                    |.::.:|...|:::      ..|..|.:.|....||||..:.::.|....|
  Rat  1280 YNGNGELINNIKYYDGFMGQRV------GAISCLAFHPHWPHLAVGSNDYYISVYSVEK 1332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 51/293 (17%)
WD40 repeat 447..486 CDD:293791 10/51 (20%)
WD40 repeat 494..532 CDD:293791 9/50 (18%)
WD40 repeat 537..573 CDD:293791 11/40 (28%)
WD40 repeat 580..615 CDD:293791 7/47 (15%)
WD40 repeat 620..653 CDD:293791 9/29 (31%)
WD40 repeat 661..695 CDD:293791
WD40 repeat 702..726 CDD:293791
RptorNP_001127971.2 Raptor_N 55..206 CDD:405260
COG5096 472..>696 CDD:227427
HEAT repeat 516..544 CDD:293787
HEAT repeat 557..587 CDD:293787
HEAT_2 566..668 CDD:404525
HEAT repeat 599..625 CDD:293787
HEAT repeat 640..670 CDD:293787
WD40 1027..1322 CDD:421866 59/339 (17%)
WD40 repeat 1027..1063 CDD:293791 6/45 (13%)
WD40 repeat 1069..1121 CDD:293791 13/77 (17%)
WD40 repeat 1126..1162 CDD:293791 6/37 (16%)
WD40 repeat 1170..1207 CDD:293791 10/36 (28%)
WD40 repeat 1256..1297 CDD:293791 6/40 (15%)
WD40 repeat 1304..1328 CDD:293791 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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