DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and POC1A

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_056241.3 Gene:POC1A / 25886 HGNCID:24488 Length:407 Species:Homo sapiens


Alignment Length:302 Identity:67/302 - (22%)
Similarity:123/302 - (40%) Gaps:53/302 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 IPRHARQINTLSHGEVVCAVTISNPTKYVYTGG-KGCVKVWDISQ-------PGNKNPVSQLDCL 487
            :.||.:     .|.:.|..|..|..||.:.:|. ..|:.||.:..       .|:|:.|:   |:
Human    11 LERHFK-----GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT---CV 67

  Fly   488 ------------QRDN---------------------YIRSVKLLPDGRTLIVGGEASNLSIWDL 519
                        .||.                     .:|||....||::.:...:...:.:|  
Human    68 NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW-- 130

  Fly   520 ASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDI 584
            |:...:....|:...........|||.::..|...|..:.:||..:...|..:..|....:.:|.
Human   131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195

  Fly   585 SPDGSRLWTGGLDNTVRSWDLREGRQLQQHDF-SSQIFSLGYCPTGDWLAVGMENSHVEVLHASK 648
            .|.|:.:...|:||||:.||:|..|.||.:.. |:.:..|.:.|:|::|.....:|.:::|...:
Human   196 HPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260

  Fly   649 PD-KYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPY 689
            .. .|.||.|:....::.|:..|::|.|.|.|..:..|::.:
Human   261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 65/291 (22%)
WD40 repeat 447..486 CDD:293791 12/46 (26%)
WD40 repeat 494..532 CDD:293791 8/37 (22%)
WD40 repeat 537..573 CDD:293791 8/35 (23%)
WD40 repeat 580..615 CDD:293791 14/34 (41%)
WD40 repeat 620..653 CDD:293791 6/33 (18%)
WD40 repeat 661..695 CDD:293791 7/29 (24%)
WD40 repeat 702..726 CDD:293791
POC1ANP_056241.3 WD40 11..299 CDD:238121 66/297 (22%)
WD 1 17..56 10/38 (26%)
WD40 repeat 23..59 CDD:293791 8/35 (23%)
WD 2 59..98 6/41 (15%)
WD40 repeat 64..100 CDD:293791 4/38 (11%)
WD 3 101..140 7/40 (18%)
WD40 repeat 107..140 CDD:293791 7/34 (21%)
WD 4 143..182 8/38 (21%)
WD40 repeat 148..184 CDD:293791 8/35 (23%)
WD 5 185..224 14/38 (37%)
WD40 repeat 190..226 CDD:293791 14/35 (40%)
WD 6 227..266 7/38 (18%)
WD40 repeat 232..255 CDD:293791 5/22 (23%)
WD 7 269..308 8/34 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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