DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Tle4

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006231190.1	Gene:	Tle4 / 25565	RGDID:	3868	Length:	774	Species:	Rattus norvegicus

Alignment Length:	821	Identity:	494/821 - (60%)
Similarity:	564/821 - (68%)	Gaps:	145/821 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||. .||||.  ..|..|.||||:::.:||||||.||||||||:|||||||::|||||||||||
  Rat     8 MYPQ-TRHPAP--HQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM 69

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:|||||.||.||||.:..|::|||..:|||||:|||||||||||.|||.|||.||
  Rat    70 YYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQQ- 133

  Fly   131 HGIQQLLQQIHAQQVPGGP----PQPMG----ALNPFG----------ALGATMGLPHGPQGLLN 177
                  ||..|.....|.|    |.|.|    |:.|.|          |||....||      :.
  Rat   134 ------LQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLP------IK 186

  Fly   178 KPPEHH-------RPDIKPTGLEGPAAAEERLRNSVSPA----DREKYRTRSPLDIENDSKRRKD 231
            ...:||       |..||              .:||||:    ..||:|..:  |..::||::|.
  Rat   187 DEKKHHDNDHQRDRDSIK--------------SSSVSPSASFRGSEKHRNST--DYSSESKKQKT 235

  Fly   232 EKLQ-----EDEGEKSDQDLVVDVANEMES-------HSPRPNGEHVSMEVRDRESLNGERLEKP 284
            |:.:     :.:|||||.:|||||:||..|       ||||.||            |:..||
  Rat   236 EEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENG------------LDKTRL--- 285

  Fly   285 SSSGIKQERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVN------P 340
                :|::.|.|.:..:||.||||.|:|::   ||..||.:|:.||||...||.||.|      |
  Rat   286 ----LKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRP 346

  Fly   341 KQMMPQG------------------PPPAGY------------PGAPYQRPADPYQRPP------ 369
            ....|.|                  |.|.|.            |||.|   |..:...|
  Rat   347 VPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAY---AGLHNISPQMSAAA 408

  Fly   370 ----SDPAYGRPPPMPYDPHAHVRTNGI-PHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGV 429
                :..||||.|.:.:|||.|:|...| |:.:.:.|||||||||::.:|.:||||||||||:|.
  Rat   409 AAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGP 473

  Fly   430 GIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIR 494
            ||||||||||||:||||||||||||||::|||||||||||||||.||||:||||||||.||||||
  Rat   474 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIR 538

  Fly   495 SVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIA 559
            |.:|||||||||||||||.|||||||:|||||||||||:||||||||||||||||||||||||||
  Rat   539 SCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIA 603

  Fly   560 VWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLG 624
            ||||||:.||||||||||||||||||.||::||||||||||||||||||||||||||:|||||||
  Rat   604 VWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLG 668

  Fly   625 YCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPY 689
            |||||:|||||||||:|||||.:|||||||||||||||||:||.|||||||||||||||||||||
  Rat   669 YCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPY 733

  Fly   690 GASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            |||||||||:|||||||||.|||||||||||||||||||||
  Rat   734 GASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	81/112 (72%)
		WD40	442..727	CDD:238121	259/284 (91%)
		WD40 repeat	447..486	CDD:293791	34/38 (89%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	33/35 (94%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	28/32 (88%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
Tle4	XP_006231190.1	TLE_N	16..139	CDD:397828	89/131 (68%)
		WD40	487..771	CDD:238121	259/283 (92%)
		WD40 repeat	491..530	CDD:293791	34/38 (89%)
		WD40 repeat	538..576	CDD:293791	33/37 (89%)
		WD40 repeat	581..617	CDD:293791	33/35 (94%)
		WD40 repeat	624..659	CDD:293791	31/34 (91%)
		WD40 repeat	664..697	CDD:293791	28/32 (88%)
		WD40 repeat	705..739	CDD:293791	31/33 (94%)
		WD40 repeat	746..770	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2083
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	888	1.000	Inparanoid score	I373
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm63535
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	LDO	PTHR10814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980