DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Tle4

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001289876.1	Gene:	Tle4 / 21888	MGIID:	104633	Length:	774	Species:	Mus musculus

Alignment Length:	821	Identity:	494/821 - (60%)
Similarity:	564/821 - (68%)	Gaps:	145/821 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||. .||||.  ..|..|.||||:::.:||||||.||||||||:|||||||::|||||||||||
Mouse     8 MYPQ-TRHPAP--HQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM 69

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:|||||.||.||||.:..|::|||..:|||||:|||||||||||.|||.|||.||
Mouse    70 YYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQQ- 133

  Fly   131 HGIQQLLQQIHAQQVPGGP----PQPMG----ALNPFG----------ALGATMGLPHGPQGLLN 177
                  ||..|.....|.|    |.|.|    |:.|.|          |||....||      :.
Mouse   134 ------LQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLP------IK 186

  Fly   178 KPPEHH-------RPDIKPTGLEGPAAAEERLRNSVSPA----DREKYRTRSPLDIENDSKRRKD 231
            ...:||       |..||              .:||||:    ..||:|..:  |..::||::|.
Mouse   187 DEKKHHDNDHQRDRDSIK--------------SSSVSPSASFRGSEKHRNST--DYSSESKKQKT 235

  Fly   232 EKLQ-----EDEGEKSDQDLVVDVANEMES-------HSPRPNGEHVSMEVRDRESLNGERLEKP 284
            |:.:     :.:|||||.:|||||:||..|       ||||.||            |:..||
Mouse   236 EEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENG------------LDKTRL--- 285

  Fly   285 SSSGIKQERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVN------P 340
                :|::.|.|.:..:||.||||.|:|::   ||..||.:|:.||||...||.||.|      |
Mouse   286 ----LKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRP 346

  Fly   341 KQMMPQG------------------PPPAGY------------PGAPYQRPADPYQRPP------ 369
            ....|.|                  |.|.|.            |||.|   |..:...|
Mouse   347 VPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAY---AGLHNISPQMSAAA 408

  Fly   370 ----SDPAYGRPPPMPYDPHAHVRTNGI-PHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGV 429
                :..||||.|.:.:|||.|:|...| |:.:.:.|||||||||::.:|.:||||||||||:|.
Mouse   409 AAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGP 473

  Fly   430 GIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIR 494
            ||||||||||||:||||||||||||||::|||||||||||||||.||||:||||||||.||||||
Mouse   474 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIR 538

  Fly   495 SVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIA 559
            |.:|||||||||||||||.|||||||:|||||||||||:||||||||||||||||||||||||||
Mouse   539 SCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIA 603

  Fly   560 VWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLG 624
            ||||||:.||||||||||||||||||.||::||||||||||||||||||||||||||:|||||||
Mouse   604 VWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLG 668

  Fly   625 YCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPY 689
            |||||:|||||||||:|||||.:|||||||||||||||||:||.|||||||||||||||||||||
Mouse   669 YCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPY 733

  Fly   690 GASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            |||||||||:|||||||||.|||||||||||||||||||||
Mouse   734 GASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	81/112 (72%)
		WD40	442..727	CDD:238121	259/284 (91%)
		WD40 repeat	447..486	CDD:293791	34/38 (89%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	33/35 (94%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	28/32 (88%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
Tle4	NP_001289876.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		8/16 (50%)
		TLE_N	16..139	CDD:397828	89/131 (68%)
		GP domain. /evidence=ECO:0000250\|UniProtKB:Q04727	138..205		19/86 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..163		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..358		69/215 (32%)
		CcN domain. /evidence=ECO:0000250\|UniProtKB:Q04727	206..275		26/70 (37%)
		SP domain. /evidence=ECO:0000250\|UniProtKB:Q04727	276..453		62/198 (31%)
		WD 1	486..524		33/37 (89%)
		WD40	487..771	CDD:238121	259/283 (92%)
		WD40 repeat	491..530	CDD:293791	34/38 (89%)
		WD 2	532..571		33/38 (87%)
		WD40 repeat	538..576	CDD:293791	33/37 (89%)
		WD 3	576..615		35/38 (92%)
		WD40 repeat	581..617	CDD:293791	33/35 (94%)
		WD 4	618..657		35/38 (92%)
		WD40 repeat	624..659	CDD:293791	31/34 (91%)
		WD 5	659..698		33/38 (87%)
		WD40 repeat	664..697	CDD:293791	28/32 (88%)
		WD 6	700..739		36/38 (95%)
		WD40 repeat	705..739	CDD:293791	31/33 (94%)
		WD 7	741..774		30/32 (94%)
		WD40 repeat	746..770	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2121
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	890	1.000	Inparanoid score	I389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm42796
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	LDO	PTHR10814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4593
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870