DRSC/TRiP Functional Genomics Resources

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Protein Alignment gro and Tle3

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001077396.1 Gene:Tle3 / 21887 MGIID:104634 Length:782 Species:Mus musculus


Alignment Length:818 Identity:486/818 - (59%)
Similarity:562/818 - (68%) Gaps:124/818 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||.. ||||...|...| .|||:|::.:|||:||.||||||||:|:|.:||:||||||||||||
Mouse     1 MYPQG-RHPAPHQPGQPG-FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVM 63

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:||||||||||||||::.|::|||..:|||||.|||||||||||.|||.|||.:..
Mouse    64 YYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGL 128

  Fly   131 HGI---QQLLQQIHAQQVPGGPP----------QPMG---------ALNPFGALGATMGLPHGPQ 173
            ..:   ||.||..|......|||          ||.|         .|...||||:...|     
Mouse   129 PNLPLTQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHL----- 188

  Fly   174 GLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPAD--REKYRTRSPLDIENDSKRRKDEKLQ- 235
             .:.....||..|.:        ..|....|||||::  |...:.|...|...::|:||.|:.. 
Mouse   189 -AVKDEKNHHELDHR--------ERESSTNNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDS 244

  Fly   236 ----EDEGEKSDQDLVVDVANE-------MESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGI 289
                :.:|:||| ||||||:||       ..:|||..||                 |:|  :.|:
Mouse   245 LSRYDSDGDKSD-DLVVDVSNEDPATPRVSPAHSPPENG-----------------LDK--ARGL 289

  Fly   290 KQERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVNPK---QMMPQGP 348
            |::.|.|.:..:||.||||.||||:   :|..|||.|:.||||...||.||.:..   :.||..|
Mouse   290 KKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP 354

  Fly   349 P---PAGYPGAPYQRP---ADPYQRP-------------------------PSD---------PA 373
            |   |.|...:..:.|   ...|..|                         ||.         .|
Mouse   355 PGMDPIGIMASALRTPITLTSSYPAPFAMMSHHEMNGSLTSPSAYAGLHNIPSQMSAAAAAAAAA 419

  Fly   374 YGRPP-----PMPYDPHAHVRTNGIPHP-SALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIP 432
            |||.|     .:.:|||..:|..|:|.. :::.|||||||||::.:|.:||||||.|||.|.|||
Mouse   420 YGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 484

  Fly   433 RHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVK 497
            ||||||||||||||||||||||||::||||||||||:|||||||:|:|:||||||.|||||||.|
Mouse   485 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCK 549

  Fly   498 LLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWD 562
            |||||||||||||||.|:|||||||||||||||||:||||||||||||:||||||||||||||||
Mouse   550 LLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWD 614

  Fly   563 LHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCP 627
            |||:.||||||||||||||||||.||::||||||||||||||||||||||||||:||||||||||
Mouse   615 LHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCP 679

  Fly   628 TGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGAS 692
            ||:|||||||:|:|||||.:|||||||||||||||||:||.||||||||||||||||||||||||
Mouse   680 TGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGAS 744

  Fly   693 IFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            ||||||:|||||||||.|||||||||||||||||||||
Mouse   745 IFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828 81/112 (72%)
WD40 442..727 CDD:238121 257/284 (90%)
WD40 repeat 447..486 CDD:293791 32/38 (84%)
WD40 repeat 494..532 CDD:293791 34/37 (92%)
WD40 repeat 537..573 CDD:293791 32/35 (91%)
WD40 repeat 580..615 CDD:293791 31/34 (91%)
WD40 repeat 620..653 CDD:293791 27/32 (84%)
WD40 repeat 661..695 CDD:293791 31/33 (94%)
WD40 repeat 702..726 CDD:293791 22/23 (96%)
Tle3NP_001077396.1 TLE_N 9..143 CDD:397828 89/134 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..173 7/32 (22%)
GP domain. /evidence=ECO:0000250|UniProtKB:Q04724 142..209 17/80 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..357 66/190 (35%)
CcN domain. /evidence=ECO:0000250|UniProtKB:Q04724 210..278 25/68 (37%)
Nuclear localization signal. /evidence=ECO:0000255 235..238 1/2 (50%)
Herpes_BLLF1 <261..482 CDD:282904 80/239 (33%)
SP domain. /evidence=ECO:0000250|UniProtKB:Q04724 279..462 61/201 (30%)
WD40 494..779 CDD:238121 257/284 (90%)
WD 1 494..532 33/37 (89%)
WD40 repeat 499..538 CDD:293791 32/38 (84%)
WD 2 540..579 34/38 (89%)
WD40 repeat 546..584 CDD:293791 34/37 (92%)
WD 3 584..623 34/38 (89%)
WD40 repeat 589..625 CDD:293791 32/35 (91%)
WD 4 626..665 35/38 (92%)
WD40 repeat 632..667 CDD:293791 31/34 (91%)
WD 5 667..706 32/38 (84%)
WD40 repeat 672..705 CDD:293791 27/32 (84%)
WD 6 708..747 36/38 (95%)
WD40 repeat 713..747 CDD:293791 31/33 (94%)
WD 7 749..781 29/31 (94%)
WD40 repeat 754..778 CDD:293791 22/23 (96%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 249 1.000 Domainoid score I2121
eggNOG 1 0.900 - - E1_KOG0639
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 890 1.000 Inparanoid score I389
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48578
OrthoDB 1 1.010 - - D251248at33208
OrthoFinder 1 1.000 - - FOG0000904
OrthoInspector 1 1.000 - - otm42796
orthoMCL 1 0.900 - - OOG6_101214
Panther 1 1.100 - - O PTHR10814
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4593
SonicParanoid 1 1.000 - - X487
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.870

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