DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and Tle2

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:XP_011241731.1 Gene:Tle2 / 21886 MGIID:104635 Length:843 Species:Mus musculus


Alignment Length:785 Identity:411/785 - (52%)
Similarity:492/785 - (62%) Gaps:143/785 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYPSPVRHPAAGGPPPQG-PIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYV 64
            |||.. |||.   |...| |.||::.:..:||||||.||||||||:|||||||::||||||||||
Mouse     1 MYPQG-RHPT---PLQSGQPFKFSVLEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 61

  Fly    65 M-----------------------YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQV 106
            |                       |||||||||:|||||.||.|||:.:..|::|||..:|||||
Mouse    62 MAAPHQCPQGGTSYPHWPRLSPLQYYEMSYGLNIEMHKQAEIVKRLSAICAQMVPFLTQEHQQQV 126

  Fly   107 LQAVERAKQVTMQELNLIIGHQQQHGIQQLLQQI-HAQQVPGGPPQPMGALNPFGALGATMGLPH 170
            ||||:||||||:.|||.::|.|.|      ||.: ||..||..|       .|.|.:||      
Mouse   127 LQAVDRAKQVTVGELNSLLGQQNQ------LQPLSHAPPVPLTP-------RPAGLVGA------ 172

  Fly   171 GPQGLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSV-----------SPADREKYRTRSPLD--- 221
            |..|||              .|.|..||:.:|..:|           |..||...|:.||..   
Mouse   173 GATGLL--------------ALSGALAAQAQLVAAVKEDRVGVDAEGSRVDRAASRSSSPSPPES 223

  Fly   222 -IEND----------SKRRKDEKLQ---EDEGEKSDQDLVVDVANEMESHSP--RPNGEHVSMEV 270
             :|.|          .:|.:|:.|.   :.|.:|||.:||||.....|..||  .|.|: ..:.:
Mouse   224 LVEEDHPSSRGGSGKQQRAEDKDLSGPYDSEEDKSDYNLVVDEDQPSEPPSPVTTPCGK-APLCI 287

  Fly   271 RDRESLNGERLEKPSS--SGIKQERPPSR--------SGSSSSRSTPSLKTKDMEKPGTPGAK-- 323
            ..|..|.    :.|:|  |.:....|.|:        :|:.:|||..:...:|...||...|.  
Mouse   288 PARRDLT----DSPASLASSLGSPLPRSKDIALNDLPTGTPASRSCGTSPPQDSSTPGPSSASHL 348

  Fly   324 ---ARTPTPNAAAPAPGVNPKQMMPQGPP-------------------PAGYPGAPYQRPADPYQ 366
               |..|    |||...:..:..:....|                   |..|.|. :..|     
Mouse   349 CQLAAQP----AAPTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYVGL-HLSP----- 403

  Fly   367 RPPSDPAYGRPP-PMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVG 430
            :..|...|||.| .|.::.|.|:|.:.:..| .:...|||||||::.:|.:||||||.|||||.|
Mouse   404 QVSSSVVYGRSPLQMAFESHPHLRGSSVSLP-GIPVAKPAYSFHVSADGQMQPVPFPSDALVGTG 467

  Fly   431 IPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRS 495
            |||||||::||:|||||||||||:.|::|||||||||||||:.|||:|.||:|||||.|||||||
Mouse   468 IPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGKGCVKVWDVGQPGSKTPVAQLDCLNRDNYIRS 532

  Fly   496 VKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAV 560
            .||||||::||||||||.|||||||:|||||||||||:||||||||:|||:||||||||||||.|
Mouse   533 CKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVV 597

  Fly   561 WDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGY 625
            |||.|:.:|||||||||||||||||..|:||||||||||||.||||||||||||||||||||||:
Mouse   598 WDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGH 662

  Fly   626 CPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYG 690
            ||..||||||||:|||||||..||:||||.|||||||||:||:||:|||||||||||||||||||
Mouse   663 CPNQDWLAVGMESSHVEVLHVRKPEKYQLRLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYG 727

  Fly   691 ASIFQ 695
            |||||
Mouse   728 ASIFQ 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828 78/136 (57%)
WD40 442..727 CDD:238121 215/254 (85%)
WD40 repeat 447..486 CDD:293791 29/38 (76%)
WD40 repeat 494..532 CDD:293791 32/37 (86%)
WD40 repeat 537..573 CDD:293791 28/35 (80%)
WD40 repeat 580..615 CDD:293791 30/34 (88%)
WD40 repeat 620..653 CDD:293791 25/32 (78%)
WD40 repeat 661..695 CDD:293791 30/33 (91%)
WD40 repeat 702..726 CDD:293791
Tle2XP_011241731.1 TLE_N 1..152 CDD:367727 87/160 (54%)
PHA03247 <269..459 CDD:223021 52/205 (25%)
WD40 466..723 CDD:392136 214/256 (84%)
WD40 repeat 484..523 CDD:293791 29/38 (76%)
WD40 repeat 531..569 CDD:293791 32/37 (86%)
WD40 repeat 574..610 CDD:293791 28/35 (80%)
WD40 repeat 617..652 CDD:293791 30/34 (88%)
WD40 repeat 657..692 CDD:293791 27/34 (79%)
WD40 repeat 698..724 CDD:293791 22/25 (88%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 153 1.000 Domainoid score I4272
eggNOG 1 0.900 - - E1_KOG0639
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 890 1.000 Inparanoid score I389
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D251248at33208
OrthoFinder 1 1.000 - - FOG0000904
OrthoInspector 1 1.000 - - otm42796
orthoMCL 1 0.900 - - OOG6_101214
Panther 1 1.100 - - O PTHR10814
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X487
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.830

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