DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Tle1

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_017175593.1	Gene:	Tle1 / 21885	MGIID:	104636	Length:	822	Species:	Mus musculus

Alignment Length:	863	Identity:	488/863 - (56%)
Similarity:	562/863 - (65%)	Gaps:	174/863 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPS---PVRHPAAGGPPPQG---PIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEM 59
            |:|.   ||.|......|.|.   |.||||.::|:||||||.||||||||:|||||||::|||||
Mouse     1 MFPQSRHPVPHAGHLQTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEM 65

  Fly    60 QRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLI 124
            |||||||||||||||:||||||||||||||:..|::|||..:|||||.|||||||||||.|||.|
Mouse    66 QRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAI 130

  Fly   125 IGHQQQHGIQQLLQQIHAQQVP--GGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDI 187
            ||.:...|:....||:.||.:.  .|||.|:              .|| |.||  :|     |.|
Mouse   131 IGVRGLPGLPPTQQQLQAQHLSHGHGPPVPL--------------TPH-PSGL--QP-----PGI 173

  Fly   188 KPTG-------LEGPAAAEERL--RNSVSPADREKYRTRSP---------------------LDI 222
            .|.|       |....:.:..|  ::.....|.|::|.|.|                     .:.
Mouse   174 PPLGGSASLLALSSALSGQSHLAIKDDKKHHDAERHRDREPGTSNSLLVPDSLRGTDKRRNGPEF 238

  Fly   223 ENDSKRRK--DEKLQEDEGEKSDQDLVVDVANEMES-------HSPRPNGEHVSMEVRDRESLNG 278
            .:|.|:||  |:...:.:|:|||.:|||||:||..|       ||||.||            ::.
Mouse   239 SSDIKKRKVDDKDNYDSDGDKSDDNLVVDVSNEDPSSPHASPTHSPRENG------------IDK 291

  Fly   279 ERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDM---EKPGTPGAKARTPTPNAAAPAPGVN- 339
            .||.|..:||       |.:.::||.|:.|||:|::   ||..||..|:.||||.:..|.||.:
Mouse   292 NRLLKKDASG-------SPASTASSGSSSSLKSKEVSLHEKANTPVLKSSTPTPRSDMPTPGTSA 349

  Fly   340 ----------PKQMMP------------------------------------------------- 345
                      |..|.|
Mouse   350 TPGLRPGLGKPPAMEPLVNQAGFGFHLELVPGSGKFGLKEKSWILSRKSSFEIKSAAGLRTPLAV 414

  Fly   346 QGPPPAGY--------------PGAPY--------QRPADPYQRPPSDPAYGRPPPMPYDPHAHV 388
            .||.||.:              |||.|        |..|.......:..||||.|.:.:||..|:
Mouse   415 PGPYPAPFGMVPHAGMNGELTSPGAAYAGLHSMSPQMSAAAAAAAAAVVAYGRSPMVGFDPPPHM 479

  Fly   389 RTNGI-PHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTI 452
            |...| |:.:.:.|||||||||:..:|.:||||||||||:|.||||||||||||:||||||||||
Mouse   480 RVPSIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTI 544

  Fly   453 SNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIW 517
            ||||::|||||||||||||||.||||:||||||||.|||||||.||||||.|||||||||.||||
Mouse   545 SNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIW 609

  Fly   518 DLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCI 582
            |||:|||||||||||:||||||||||||||||||||||||||||||||:.|||||||||||||||
Mouse   610 DLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCI 674

  Fly   583 DISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHAS 647
            |||.||::||||||||||||||||||||||||||:||||||||||||:|||||||:|:|||||.:
Mouse   675 DISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVN 739

  Fly   648 KPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDK 712
            |||||||||||||||||:||.||||||||||||||||||||||||||||||:|||||||||.|||
Mouse   740 KPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDK 804

  Fly   713 YIVTGSGDKKATVYEVIY 730
            ||||||||||||||||||
Mouse   805 YIVTGSGDKKATVYEVIY 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	86/115 (75%)
		WD40	442..727	CDD:238121	258/284 (91%)
		WD40 repeat	447..486	CDD:293791	34/38 (89%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	33/35 (94%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	27/32 (84%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
Tle1	XP_017175593.1	TLE_N	1..151	CDD:367727	99/149 (66%)
		WD40	535..819	CDD:238121	258/283 (91%)
		WD40 repeat	539..578	CDD:293791	34/38 (89%)
		WD40 repeat	586..624	CDD:293791	33/37 (89%)
		WD40 repeat	629..665	CDD:293791	33/35 (94%)
		WD40 repeat	672..707	CDD:293791	31/34 (91%)
		WD40 repeat	712..745	CDD:293791	27/32 (84%)
		WD40 repeat	753..787	CDD:293791	31/33 (94%)
		WD40 repeat	794..818	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2121
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	890	1.000	Inparanoid score	I389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48578
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm42796
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830