DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and wdr-48

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001129837.1	Gene:	wdr-48 / 175600	WormBaseID:	WBGene00009441	Length:	697	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	67/310 - (21%)
Similarity:	128/310 - (41%)	Gaps:	52/310 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 VRTNGIPHPSALTGGKPAYSFH--MNGEGSLQPVPFPPDALVGVGIPRHARQINTL---SHGEVV 447
            :||..:||      .|.|:|..  :...|...||.:..      .:.:|...:|.:   .||:::
Worm    53 IRTWSVPH------HKDAFSARGGVRSPGKNSPVQYQG------SLEQHTDWVNDMILCGHGKIL 105

  Fly   448 CAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQ-RDNYIRSVKLLPDGRTLIVGGEA 511
              ::.||.|         .||||:|.: .||:  ..:||:: ..:|:..:...|.....:.....
Worm   106 --ISASNDT---------TVKVWNIER-DNKH--GFIDCIRTHKDYVSCLAYAPIVEKAVSASFD 156

  Fly   512 SNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHT 576
            .|:.::|:.:....:. .|.....:.|:||.:|:..:.....::..|.::|......:.:.:|||
Worm   157 HNIFVYDINANFKTVN-NLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDPRTNEKIMKLRGHT 220

  Fly   577 DGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYC---PTGDWLAVGMEN 638
            |....:.::.||:|..:.|.|.|:|.||:.:.|            .:..|   ..|.| .:.:::
Worm   221 DNVRALVVNDDGTRALSAGSDATIRLWDIGQQR------------CIATCIAHEEGVW-TLQVDS 272

  Fly   639 SHVEVLHASKPD---KYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAW 685
            |...|..|.|..   |..|:......|..:..|..|..:.:.|||.::.|
Worm   273 SFTTVYSAGKDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDNPVSLW 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	55/251 (22%)
		WD40 repeat	447..486	CDD:293791	10/38 (26%)
		WD40 repeat	494..532	CDD:293791	4/37 (11%)
		WD40 repeat	537..573	CDD:293791	6/35 (17%)
		WD40 repeat	580..615	CDD:293791	10/34 (29%)
		WD40 repeat	620..653	CDD:293791	8/38 (21%)
		WD40 repeat	661..695	CDD:293791	7/25 (28%)
		WD40 repeat	702..726	CDD:293791
wdr-48	NP_001129837.1	WD40	2..376	CDD:225201	67/310 (22%)
		WD40	29..322	CDD:238121	66/308 (21%)
		WD40 repeat	32..88	CDD:293791	10/46 (22%)
		WD40 repeat	94..133	CDD:293791	15/52 (29%)
		WD40 repeat	138..175	CDD:293791	3/37 (8%)
		WD40 repeat	182..217	CDD:293791	6/34 (18%)
		WD40 repeat	223..259	CDD:293791	10/47 (21%)
		WD40 repeat	307..333	CDD:293791	5/16 (31%)
		DUF3337	530..695	CDD:288649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000