DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and wdr-83

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_494926.1	Gene:	wdr-83 / 173867	WormBaseID:	WBGene00018014	Length:	305	Species:	Caenorhabditis elegans

Alignment Length:	288	Identity:	58/288 - (20%)
Similarity:	98/288 - (34%)	Gaps:	85/288 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 LDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIW-------------------DLASPTPRIKAE 529
            :||.|  ..:|:|:...||...:..|....:.:|                   |.||.:...:..
Worm    12 IDCKQ--GAVRAVRYNVDGNYCVTCGSDKTVKLWNPLKSSLLKTYSGTGNEVLDAASSSDNSQIA 74

  Fly   530 LTSAAPAC---------------------YALAISPDSKVCFSCCSDGNIAVWDL--HNEILVRQ 571
            ...|..||                     .|:|.:.:|.|.||...|..:..:|.  .:|..::.
Worm    75 AGGADRACTVFDVETGKQLRRWRTHGAQVNAVAFNEESSVVFSGSMDCTMQAFDCRSRSEKPIQI 139

  Fly   572 FQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGM 636
            |...|||...||:  :|..:..|..|...|.:.:|:|.....: ....:.|:.:.|..:.|..|:
Worm   140 FNESTDGILSIDV--NGHEIVAGSADGNYRVYSIRDGNMTVDY-MGDSVNSVSFTPDSNCLLAGV 201

  Fly   637 ENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSS 701
            ....|.::     ||                       |:||  ||        ||....:.|..
Worm   202 MGGIVRLI-----DK-----------------------SSGK--LL--------ASYKGHQNTEY 228

  Fly   702 VLSCDISTDDKYIVTGSGDKKATVYEVI 729
            .|.|.:....:::.:||.|....||.::
Worm   229 KLDCRVLQSIEHVASGSEDGFVYVYSLL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	57/284 (20%)
		WD40 repeat	447..486	CDD:293791	0/1 (0%)
		WD40 repeat	494..532	CDD:293791	9/56 (16%)
		WD40 repeat	537..573	CDD:293791	10/58 (17%)
		WD40 repeat	580..615	CDD:293791	8/34 (24%)
		WD40 repeat	620..653	CDD:293791	7/32 (22%)
		WD40 repeat	661..695	CDD:293791	7/33 (21%)
		WD40 repeat	702..726	CDD:293791	5/23 (22%)
wdr-83	NP_494926.1	WD40	10..294	CDD:238121	58/288 (20%)
		WD40 repeat	21..56	CDD:293791	5/34 (15%)
		WD40 repeat	62..98	CDD:293791	6/35 (17%)
		WD40 repeat	103..141	CDD:293791	9/37 (24%)
		WD40 repeat	148..180	CDD:293791	8/33 (24%)
		WD40 repeat	185..221	CDD:293791	14/73 (19%)
		WD40 repeat	229..265	CDD:293791	7/28 (25%)
		WD40 repeat	271..294	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910