DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and TLE5

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_945320.1 Gene:TLE5 / 166 HGNCID:307 Length:264 Species:Homo sapiens


Alignment Length:229 Identity:105/229 - (45%)
Similarity:130/229 - (56%) Gaps:47/229 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 PQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVMYYEMSYGLNVEMHKQ 80
            || .:|||.:|:.:|||:||..|||||||:||||:||::||:|||||||||||||||||:|||||
Human    82 PQ-QLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQ 145

  Fly    81 TEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQHGIQQLLQQIHAQQV 145
            .||.||||.:..|:||:|..:||||||.|:|||||||..|||.||..|.|   ...|.|:.|..:
Human   146 AEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQ---AHQLSQLQALAL 207

  Fly   146 PGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKP-TGLEGPAAAEERLRNSVSPA 209
            |         |.|.            |.||  :||.  .|.:.. |||...:|...:...|    
Human   208 P---------LTPL------------PVGL--QPPS--LPAVSAGTGLLSLSALGSQAHLS---- 243

  Fly   210 DREKYRTRSPLDIENDSKRRKDEKLQEDEGEKSD 243
                         :.|......:..|||:|||||
Human   244 -------------KEDKNGHDGDTHQEDDGEKSD 264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828 75/107 (70%)
WD40 442..727 CDD:238121
WD40 repeat 447..486 CDD:293791
WD40 repeat 494..532 CDD:293791
WD40 repeat 537..573 CDD:293791
WD40 repeat 580..615 CDD:293791
WD40 repeat 620..653 CDD:293791
WD40 repeat 661..695 CDD:293791
WD40 repeat 702..726 CDD:293791
TLE5NP_945320.1 TLE_N 72..199 CDD:367727 79/120 (66%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1980
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.760

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