DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Tle5

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_034477.1	Gene:	Tle5 / 14797	MGIID:	95806	Length:	197	Species:	Mus musculus

Alignment Length:	244	Identity:	109/244 - (44%)
Similarity:	136/244 - (55%)	Gaps:	49/244 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |:|.. ||..:...|.|  :|||.:|:.:|||:||..|||||||:||||:||::||:||||||||
Mouse     2 MFPQS-RHSGSSHLPQQ--LKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVM 63

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQ 130
            |||||||||:|||||.||.||||.:..|:||:|..:||||||.|:|||||||..|||.||..|.|
Mouse    64 YYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQ 128

  Fly   131 HGIQQLLQQIHAQQVPGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKP-TGLEG 194
               ...|.|:.|..:|         |.|.            |.||  :||.  .|.:.. |||..
Mouse   129 ---AHQLSQLQALALP---------LTPL------------PVGL--QPPS--LPAVSAGTGLLS 165

  Fly   195 PAAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDEKLQEDEGEKSD 243
            .:|...:...|                 :.|......:..|||:|||||
Mouse   166 LSALGSQTHLS-----------------KEDKNGHDGDTHQEDDGEKSD 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	75/112 (67%)
		WD40	442..727	CDD:238121
		WD40 repeat	447..486	CDD:293791
		WD40 repeat	494..532	CDD:293791
		WD40 repeat	537..573	CDD:293791
		WD40 repeat	580..615	CDD:293791
		WD40 repeat	620..653	CDD:293791
		WD40 repeat	661..695	CDD:293791
		WD40 repeat	702..726	CDD:293791
Tle5	NP_034477.1	TLE_N	11..132	CDD:397828	79/125 (63%)
		CCN domain	166..197		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..197		8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1980
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760