DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and AgaP_AGAP009046

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_319798.2	Gene:	AgaP_AGAP009046 / 1280004	VectorBaseID:	AGAP009046	Length:	503	Species:	Anopheles gambiae

Alignment Length:	579	Identity:	118/579 - (20%)
Similarity:	204/579 - (35%)	Gaps:	161/579 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 GLEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDEKLQEDEGEKSDQDLVVDVANEME 255
            |.:..||.:.:.| ||..|..||...||.......||::......:..|.|.:::|
Mosquito     2 GADKKAAGKSQDR-SVKKAKEEKGSVRSGKIKSKVSKKKAKASAIDQPGSKQEKEL--------- 56

  Fly   256 SHSPRPNGEHVSMEVRDRESL--NGERLEKPSSSGIKQERPPSRSG-SSSSRSTPSLK------T 311
                      :|:....::.|  |..:.||.|     .:..|::.| ...::.||..:      :
Mosquito    57 ----------MSLVFGGKDELVSNLTKSEKKS-----DKTDPAQGGKKKQAKQTPKKRRAVWHDS 106

  Fly   312 KDMEKPGTPGAKARTPTPNAAAPAPGVNPKQMMPQGPPP--AGYPGAPYQRPADPYQRPPSDPAY 374
            .|.::..|...|....|.:..       |:|:..:....  ....|.|.....|..:.|.||
Mosquito   107 DDDDEEDTVNMKRNKFTYDEL-------PEQLTKERRRKQFEQIVGQPKWADLDRVREPDSD--- 161

  Fly   375 GRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFH-MNGEGSLQPVPFPPDALVGVGIPRHARQI 438
                      ...::|.|                | :.|.|:.|            |:|:...::
Mosquito   162 ----------EEMLQTVG----------------HVVKGAGASQ------------GLPKGMIEL 188

  Fly   439 NTLSH--------GEVVCAVTIS-NPTKYV--YTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNY 492
            ..|.:        |::.|   |: :||..|  .||.:|.|.:  ::..|.:|.......||:..
Mosquito   189 KKLKNLNRETKIEGKISC---INFHPTSMVAMMTGNRGLVSI--VAVDGVRNEKLHTLWLQKVR- 247

  Fly   493 IRSVKLLPDGRTLIVG-------------GEASNLSI-----WD------------LASPTPRIK 527
            |...:|.|||...|.|             |::..|.|     |.            |||.....:
Mosquito   248 ISCSRLSPDGNEAIFGSYRKFFHVYNLLSGQSDTLKIPERDTWQMKNFRISRCGKYLASVGECGE 312

  Fly   528 AELTSAAP-----------ACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQ--GHTDGA 579
            ..|..|..           .|.:||.:|||:......:|..::|:.|..:.:|..||  |..:|
Mosquito   313 VHLMDARTKDVLQTIQLRYTCQSLAFTPDSRYLLCHSNDTEVSVFSLEQKRIVNVFQDEGCVNG- 376

  Fly   580 SCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQ-------HDFSSQIFSLGYCPTGDWLAVG-- 635
            |||.|.|:|..:.||.....|..:.|......:|       ::.::.|.||.:..|.:.|.:.
Mosquito   377 SCIAICPNGQFVATGSRQGIVNLYTLEVTLTEKQPVPVKTFNNLTTYIDSLAFNATSELLVIASS 441

  Fly   636 -MENSHVEVLHASKPD---KYQLHL-HESCVLSLRFAACGKWFVSTGKDNLLNAWRTPY 689
             ::|: |.::|.....   .:.||: |...|.:..|:..|.:.....|.:.:..:|..:
Mosquito   442 TVKNA-VRLIHVKSRTVFRNFPLHMTHLGHVSAAEFSPLGGYLALGTKQSTVLLFRVKH 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	71/316 (22%)
		WD40 repeat	447..486	CDD:293791	11/41 (27%)
		WD40 repeat	494..532	CDD:293791	14/67 (21%)
		WD40 repeat	537..573	CDD:293791	10/35 (29%)
		WD40 repeat	580..615	CDD:293791	11/41 (27%)
		WD40 repeat	620..653	CDD:293791	8/38 (21%)
		WD40 repeat	661..695	CDD:293791	5/29 (17%)
		WD40 repeat	702..726	CDD:293791
AgaP_AGAP009046	XP_319798.2	WD40	<177..498	CDD:225201	75/340 (22%)
		WD40 repeat	204..243	CDD:293791	11/43 (26%)
		WD40	237..498	CDD:295369	59/263 (22%)
		WD40 repeat	249..292	CDD:293791	10/42 (24%)
		WD40 repeat	297..328	CDD:293791	5/30 (17%)
		WD40 repeat	333..371	CDD:293791	12/37 (32%)
		WD40 repeat	377..419	CDD:293791	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910