DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and AgaP_AGAP010324

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_318239.4	Gene:	AgaP_AGAP010324 / 1278620	VectorBaseID:	AGAP010324	Length:	752	Species:	Anopheles gambiae

Alignment Length:	792	Identity:	512/792 - (64%)
Similarity:	576/792 - (72%)	Gaps:	102/792 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPS--------PVRHPAAGGPPPQG-PIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEK 56
            |||:        ..|||   |||... |.||||.:..:||||||||||||||::|:|||||:.:|
Mosquito     1 MYPNSGINAAAVAARHP---GPPQSAQPFKFTITENCDRIKEEFNFLQAQYHNLKMECEKLAQDK 62

  Fly    57 TEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQEL 121
            |||||||||||||||||||||||||||:||||.:|.|::|||..:||||||.|||||||:||.||
Mosquito    63 TEMQRHYVMYYEMSYGLNVEMHKQTEISKRLNAIITQIVPFLSQEHQQQVLTAVERAKQITMSEL 127

  Fly   122 NLIIGHQQQHGIQQLLQQIHAQQVP---GGPPQPMGALNPF---GALGATMGL----PHGPQGLL 176
            |.:||.||:..:.:||||:||||:|   |.||.|:|..:|.   ||||..:.|    |..|..:|
Mosquito   128 NSVIGQQQRPDLPRLLQQMHAQQIPGAHGAPPIPVGMPHPSLGPGALGGPLALGSTPPQHPLAIL 192

  Fly   177 NKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDEK-LQEDEGE 240
            || .|.|||:...:........::|.|:|:||:||:|||.|:|.......|.:|:|| |...:||
Mosquito   193 NK-QELHRPEESKSSNSNIMPLDDRHRSSISPSDRDKYRPRTPESTHELKKVKKEEKDLGHSDGE 256

  Fly   241 KSDQDLVVDVANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQER-----------P 294
            |||||||||.|:|....||.||..|           ||  ...|..:|:.|::           .
Mosquito   257 KSDQDLVVDDASETNPMSPIPNQHH-----------NG--TASPRENGMMQKKLDVQDRDRIGTH 308

  Fly   295 PSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPT--------PNAAAPAPGVNPKQMMPQGPPPA 351
            ..|||:||:.||||.|..| :||.||.||..|||        |......|.:||
Mosquito   309 SPRSGTSSNASTPSNKKLD-DKPTTPIAKPATPTNSVASNGVPKVVNKPPVINP----------- 361

  Fly   352 GYP----GAPYQRPADPYQRPPSDPAYGRP---------------PPMPYDPHAHVRTN----GI 393
            |||    |||:.     .|...:..|||.|               .|:.:|||:.:|..    ||
Mosquito   362 GYPPYLAGAPHD-----LQAAAAAAAYGGPGVHNNLPHSLNNYARAPLAFDPHSQMRAPLGPIGI 421

  Fly   394 PHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKY 458
            |      |||||||||:|.||.:||||||.|||||.|||||||||::|:||||||||||||||||
Mosquito   422 P------GGKPAYSFHVNAEGQMQPVPFPQDALVGPGIPRHARQISSLNHGEVVCAVTISNPTKY 480

  Fly   459 VYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPT 523
            ||||||||||.|||||||||:||||||||||||||||||||||||||||||||||||||||||||
Mosquito   481 VYTGGKGCVKAWDISQPGNKSPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPT 545

  Fly   524 PRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDG 588
            |||||||||.||||||||||||||||||||||||||||||.|:.||||||||||||||||||.||
Mosquito   546 PRIKAELTSNAPACYALAISPDSKVCFSCCSDGNIAVWDLQNQTLVRQFQGHTDGASCIDISADG 610

  Fly   589 SRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQ 653
            |:|||||||||||||||||||||||||||||||||||||||:|||||||||:||||||:||||||
Mosquito   611 SKLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGEWLAVGMENSNVEVLHATKPDKYQ 675

  Fly   654 LHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGS 718
            |||||||||||:|||||||||||||||||||||||||||||||||:|||||||||.|||||||||
Mosquito   676 LHLHESCVLSLKFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGS 740

  Fly   719 GDKKATVYEVIY 730
            ||||||||||||
Mosquito   741 GDKKATVYEVIY 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	83/113 (73%)
		WD40	442..727	CDD:238121	269/284 (95%)
		WD40 repeat	447..486	CDD:293791	36/38 (95%)
		WD40 repeat	494..532	CDD:293791	37/37 (100%)
		WD40 repeat	537..573	CDD:293791	32/35 (91%)
		WD40 repeat	580..615	CDD:293791	32/34 (94%)
		WD40 repeat	620..653	CDD:293791	29/32 (91%)
		WD40 repeat	661..695	CDD:293791	32/33 (97%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
AgaP_AGAP010324	XP_318239.4	TLE_N	1..142	CDD:281857	93/143 (65%)
		WD40	<464..750	CDD:225201	270/285 (95%)
		WD40	465..708	CDD:238121	230/242 (95%)
		WD40 repeat	469..508	CDD:293791	36/38 (95%)
		WD40 repeat	516..554	CDD:293791	37/37 (100%)
		WD40 repeat	559..595	CDD:293791	32/35 (91%)
		WD40 repeat	602..637	CDD:293791	32/34 (94%)
		WD40 repeat	642..675	CDD:293791	29/32 (91%)
		WD40 repeat	683..717	CDD:293791	32/33 (97%)
		WD40 repeat	724..748	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I7046
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D12238at7147
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X487
TreeFam	0	0.000	Not matched by this tool.
	7	6.830