DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and AgaP_AGAP009506

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_310190.3	Gene:	AgaP_AGAP009506 / 1271405	VectorBaseID:	AGAP009506	Length:	350	Species:	Anopheles gambiae

Alignment Length:	375	Identity:	88/375 - (23%)
Similarity:	138/375 - (36%)	Gaps:	89/375 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 QRPADPYQRPPSDPAYGRPPPMPYDP------HAHV-RTNGIPHPSALTGGKP----AYSFHMNG 412
            :||:|... |..:|...|...:.|..      ..:| ||:|:..|..|..|..    :..||..|
Mosquito     7 KRPSDALV-PVVNPKKSRTDIVAYTAKDKQLLEQNVERTSGLLGPIMLLEGHGGEIFSTEFHPEG 70

  Fly   413 EGSLQPVPFPPDALVGVGIPR---------HARQINTLS-HGEVVCAVTISNPTKYVYTGGKGC- 466
            |           .|:..|..|         ....:..|| |...|.....|.....:||    |
Mosquito    71 E-----------HLLSTGFDRQIFLWKVYDECENVGVLSGHSGAVMEAHFSPDGSNIYT----CA 120

  Fly   467 ----VKVWDISQPGNKNPVSQLDCLQ------RDNYIRSVKLLPDGRTLIV-GGEASNLSIWDLA 520
                |.|||:.           .|.:      ..:::.|......|.|||| |.:.:::.|||..
Mosquito   121 TDKVVGVWDVP-----------TCTRIRKLKGHTHFVNSCSGARRGPTLIVSGSDDASIKIWDAR 174

  Fly   521 SPTPRIKAELTSAAPACYALAISPDSKVCFSCCS--------DGNIAVWDLHNEILVRQFQGHTD 577
                  |..:.|.....|.:     :.|||:..:        |..|.|||:..:.::.:.:||||
Mosquito   175 ------KRHVVSTFDNTYQV-----TAVCFNDTAEQVVSGGIDNEIKVWDIRKKEILYRLRGHTD 228

  Fly   578 GASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQ---------QHDFSSQIFSLGYCPTGDWLA 633
            ..:.:.:|||||.:.:..:|||:|.||:|.....:         ||:|...:....:.|.|..::
Mosquito   229 TVTGLSLSPDGSYVLSNSMDNTLRIWDIRPYVPAERCVKVFTGHQHNFEKNLLRCAWSPDGLKIS 293

  Fly   634 VGMENSHVEVLH-ASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLL 682
            .|..:..|.:.. .|:...|:|..|...|..:.|.......||...|..|
Mosquito   294 AGSADRFVYIWDTTSRRILYKLPGHNGSVNDIDFHPTEPIIVSGSSDKTL 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	66/272 (24%)
		WD40 repeat	447..486	CDD:293791	9/43 (21%)
		WD40 repeat	494..532	CDD:293791	11/38 (29%)
		WD40 repeat	537..573	CDD:293791	9/43 (21%)
		WD40 repeat	580..615	CDD:293791	13/43 (30%)
		WD40 repeat	620..653	CDD:293791	5/33 (15%)
		WD40 repeat	661..695	CDD:293791	6/22 (27%)
		WD40 repeat	702..726	CDD:293791
AgaP_AGAP009506	XP_310190.3	WD40	52..>345	CDD:225201	76/329 (23%)
		WD40	54..345	CDD:238121	75/327 (23%)
		WD40 repeat	61..99	CDD:293791	8/48 (17%)
		WD40 repeat	105..141	CDD:293791	9/50 (18%)
		WD40 repeat	146..183	CDD:293791	12/42 (29%)
		WD40 repeat	189..224	CDD:293791	8/34 (24%)
		WD40 repeat	230..270	CDD:293791	12/39 (31%)
		WD40 repeat	280..316	CDD:293791	6/35 (17%)
		WD40 repeat	322..345	CDD:293791	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910