DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and Tle6

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006513144.1	Gene:	Tle6 / 114606	MGIID:	2149593	Length:	609	Species:	Mus musculus

Alignment Length:	599	Identity:	145/599 - (24%)
Similarity:	251/599 - (41%)	Gaps:	142/599 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 EGPAAAEERLRNSVSPADRE----------KYR-TRSPLDIENDSKRR---KDEKLQE-----DE 238
            |.|..:.:...||....|::          |:: |..|   :..::||   :.::||:     |.
Mouse    92 EAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGP---QLPTRRRFLSESDELQDPQPVWDA 153

  Fly   239 GEKSDQDLVVDVANEMESHSPRPN-----GEHVSMEVRDRESLNGERLEKPSSSGI---KQERPP 295
            ..:..|..::....|:...|.:.|     ||..|.|.:|              ||:   |.|..|
Mouse   154 EPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKD--------------SGLCDFKPEPQP 204

  Fly   296 SRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPNAAAPAPGVNPKQMMPQGPPPAGYPGAPYQR 360
            ....|.|..:.|.|                ..:|:|.......:..:..|:....:|
Mouse   205 RHRNSLSDSADPFL----------------IKSPSALLDYYQEDVSRPQPETQESSG-------- 245

  Fly   361 PADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDA 425
            .||.:.:|.|   :|          :.|..:....||........::
Mouse   246 RADKFLKPLS---WG----------SEVLESSCNQPSTALWQLERFT------------------ 279

  Fly   426 LVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWD-ISQPG-NKNPVSQLDC-- 486
                 :|:..:::..|.|.|::..|.:|:.|::|:|..:..:|||: ::|.. :::|.|.|.|
Mouse   280 -----VPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSV 339

  Fly   487 ---------------------LQRDN-------YIRSVKLLPDGRTLIVGG-EASNLSIWDLASP 522
                                 .:||:       |:|:..|..:.|||..|| ....:.:||||:|
Mouse   340 QVTGQGRGWGWEVLEEPRLTLTRRDDPLQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAP 404

  Fly   523 TPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPD 587
            :...|.:|.....:|.|||.:.:: :..:..:||.:.:|||..:.:||..:|.|:.|..:.:..|
Mouse   405 SLYEKCQLPCEGLSCQALANTKEN-MALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDD 468

  Fly   588 GSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK- 651
              .:||||||..:|.||||..:...:|.|.|||.||.:.||.|||.:|:.|....:.::.|.|:
Mouse   469 --NIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQV 531

  Fly   652 YQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVT 716
            ..:...::.:|.|:|:..|||:.|.|..|.:.....|.||.:||..|...|...|::.:.:.|:|
Mouse   532 LTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIIT 596

  Fly   717 GSGDKKATVYEVIY 730
            ||.| .|:||.:.|
Mouse   597 GSRD-CASVYHIKY 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	98/318 (31%)
		WD40 repeat	447..486	CDD:293791	12/40 (30%)
		WD40 repeat	494..532	CDD:293791	14/38 (37%)
		WD40 repeat	537..573	CDD:293791	11/35 (31%)
		WD40 repeat	580..615	CDD:293791	12/34 (35%)
		WD40 repeat	620..653	CDD:293791	12/33 (36%)
		WD40 repeat	661..695	CDD:293791	12/33 (36%)
		WD40 repeat	702..726	CDD:293791	8/23 (35%)
Tle6	XP_006513144.1	WD40	287..601	CDD:392136	97/317 (31%)
		WD40 repeat	299..369	CDD:293791	15/69 (22%)
		WD40 repeat	375..413	CDD:293791	13/37 (35%)
		WD40 repeat	417..454	CDD:293791	11/37 (30%)
		WD40 repeat	462..494	CDD:293791	12/33 (36%)
		WD40 repeat	499..533	CDD:293791	12/33 (36%)
		WD40 repeat	541..575	CDD:293791	12/33 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.800