DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and Wdr74

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_598900.1 Gene:Wdr74 / 107071 MGIID:2147427 Length:384 Species:Mus musculus


Alignment Length:233 Identity:51/233 - (21%)
Similarity:88/233 - (37%) Gaps:32/233 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   427 VGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRD- 490
            ||.|:.| .||..|.:|....|             |.:..:||||:.  |::.||.:...::.| 
Mouse   129 VGPGVCR-MRQDPTHTHVVATC-------------GKENALKVWDLQ--GSEEPVFRAKNVRNDW 177

  Fly   491 ------NYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVC 549
                  .:.:..:.||..:.|:.......:.::|..||..|...|.|.......|:.::|:....
Mouse   178 LDLRVPIWDQDTQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEATYGEYPLTAMTLTPEGNSV 242

  Fly   550 FSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQH 614
            ....:.|.:|..|.....|:...:|.......:...|....|.:.|||..:|...:|..|.|:..
Mouse   243 IVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHK 307

  Fly   615 DF-SSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDK 651
            .: .||:..|        |..|.:|...|.....:|::
Mouse   308 VYLKSQLNCL--------LLSGRDNWEDEPQEPQEPNQ 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 44/218 (20%)
WD40 repeat 447..486 CDD:293791 9/38 (24%)
WD40 repeat 494..532 CDD:293791 8/37 (22%)
WD40 repeat 537..573 CDD:293791 6/35 (17%)
WD40 repeat 580..615 CDD:293791 9/34 (26%)
WD40 repeat 620..653 CDD:293791 6/32 (19%)
WD40 repeat 661..695 CDD:293791
WD40 repeat 702..726 CDD:293791
Wdr74NP_598900.1 WD 1 40..80
WD40 <42..295 CDD:225201 39/181 (22%)
WD40 45..302 CDD:295369 41/188 (22%)
WD 2 83..122
WD40 repeat 91..127 CDD:293791
WD 3 128..168 16/54 (30%)
WD40 repeat 133..171 CDD:293791 14/53 (26%)
WD 4 179..220 7/40 (18%)
WD40 repeat 185..224 CDD:293791 8/38 (21%)
WD 5 224..266 7/41 (17%)
WD40 repeat 230..266 CDD:293791 6/35 (17%)
WD 6 267..306 10/38 (26%)
Required for nucleolar and nuclear location. /evidence=ECO:0000250|UniProtKB:Q6RFH5 320..384 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..384 3/15 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.