DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gro and TLE7

DIOPT Version :9

Sequence 1:NP_996298.1 Gene:gro / 43162 FlyBaseID:FBgn0001139 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_001354294.1 Gene:TLE7 / 102723796 HGNCID:53648 Length:441 Species:Homo sapiens


Alignment Length:416 Identity:148/416 - (35%)
Similarity:225/416 - (54%) Gaps:62/416 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   355 GAPYQRPADPYQRPPSD-------------PAYGRPPPMPYDPHAHVRTNGIP----------HP 396
            |.|:|.|..|.|..|:|             ...||         :.::..|:|          .|
Human    48 GVPWQPPGPPIQHSPADQETSTVTQQQWHLQGLGR---------SELQAAGLPDAQPGEAAESSP 103

  Fly   397 SALTG---GKPAYSFHMNGE---GSLQPVPFPPDALV--GVGIPRHARQINTLSHGEVVCAVTIS 453
            |.|.|   |:| ||.....|   ..|:.:|..||.:|  ....|:.:.::.||.||:.|.||.||
Human   104 SFLLGSEVGQP-YSSSSPSEEVLSLLRAIPPIPDEVVVRQKRAPQGSWKVGTLFHGKRVYAVAIS 167

  Fly   454 NPTKYVYTGGKGCVKVWDIS--QPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSI 516
            ..|.:|||.|.|.::|||.|  ..|.|.|.:|||.....:.:.:.||.||.|:||.||.:..:::
Human   168 GSTHHVYTCGSGYIRVWDESALHAGEKAPRAQLDLQHPQDRVVTCKLFPDERSLITGGASQAVTL 232

  Fly   517 WDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASC 581
            |||| |||:::|:|||..|.||:||:|.|:.:|.: |..|.:.:|||.|:||:|:.:....|:.|
Human   233 WDLA-PTPQVRAQLTSTGPTCYSLAVSSDAHICLA-CFHGFVEIWDLQNQILIRKHEVPVYGSRC 295

  Fly   582 IDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHA 646
            :||:  |:..||||.|..:.|||||..::|.||:..::|.|:.:.|..:|:..|:..|.:..||.
Human   296 VDIT--GNIFWTGGEDTILYSWDLRSYQRLHQHNLQNEILSITHDPGEEWVLAGLRTSDIVFLHT 358

  Fly   647 SKPD-------KYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLS 704
            .:.:       ||..| |     ||:||:||.:|| |..|..|:....|....:||.:|:|.:|.
Human   359 RRNEQFKALMKKYTRH-H-----SLKFASCGSYFV-TAIDTRLSGLEAPSLQKLFQIEESSGILC 416

  Fly   705 CDISTDDKYIVTGSGDKKATVYEVIY 730
            ||:|:|::|:|.|| ...||:|:::|
Human   417 CDVSSDNQYLVMGS-SSSATIYQLLY 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
groNP_996298.1 TLE_N 11..124 CDD:397828
WD40 442..727 CDD:238121 117/293 (40%)
WD40 repeat 447..486 CDD:293791 20/40 (50%)
WD40 repeat 494..532 CDD:293791 18/37 (49%)
WD40 repeat 537..573 CDD:293791 16/35 (46%)
WD40 repeat 580..615 CDD:293791 16/34 (47%)
WD40 repeat 620..653 CDD:293791 9/39 (23%)
WD40 repeat 661..695 CDD:293791 12/33 (36%)
WD40 repeat 702..726 CDD:293791 11/23 (48%)
TLE7NP_001354294.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..77 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..119 9/28 (32%)
WD 1. /evidence=ECO:0000255 156..194 18/37 (49%)
WD40 <157..316 CDD:392136 71/162 (44%)
WD40 repeat 162..204 CDD:293791 20/41 (49%)
WD 2. /evidence=ECO:0000255 204..243 16/39 (41%)
WD40 repeat 209..245 CDD:293791 17/36 (47%)
WD 3. /evidence=ECO:0000255 247..285 17/38 (45%)
WD40 repeat 253..283 CDD:293791 13/30 (43%)
WD 4. /evidence=ECO:0000255 286..325 16/40 (40%)
WD40 repeat 290..324 CDD:293791 15/35 (43%)
WD40 repeat 332..372 CDD:293791 9/39 (23%)
WD 5. /evidence=ECO:0000255 409..441 14/32 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D546143at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10814
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.020

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