DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Tle7

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001357768.1	Gene:	Tle7 / 102638837	MGIID:	5439433	Length:	430	Species:	Mus musculus

Alignment Length:	432	Identity:	141/432 - (32%)
Similarity:	230/432 - (53%)	Gaps:	79/432 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 PYQRPADPYQRPPSDP-----AYGRPPPMP-----------------YDPHAHVRTNGIP----- 394
            |..||:...::|||..     ...|||..|                 :||||. .|:|:.
Mouse    20 PTLRPSPASRKPPSTAHCAKCLLWRPPGPPSRDSQPVTEMHSMMQQQWDPHAQ-DTSGLQSMWFS 83

  Fly   395 ------------HPSALTG--------GKPAYSFHMNGEGSLQPV-PFPPDALVGVGIPRHARQI 438
                        .|...||        .:..:||       |:.: |.|.:|:|....|..:.::
Mouse    84 EAEPEGGTGSRFQPGDKTGQFSSPSLPNREVWSF-------LKAIPPIPDEAVVKQKSPCGSWRV 141

  Fly   439 NTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDIS--QPGNKNPVSQLDCLQRDNYIRSVKLLPD 501
            .||.||:.|.|:.||:...:|||.|.|.::|||.:  ...::.|.:|||.....|.:.:.||.||
Mouse   142 GTLRHGKRVNAIAISSAPCHVYTCGTGYIRVWDENALHASDRAPQAQLDFQDPRNRVLTCKLFPD 206

  Fly   502 GRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNE 566
            .::||.||.|..|::|||| |||:::|::.|....||:||:|.|:.:|.:... |.:.:||:.|:
Mouse   207 EQSLITGGMARGLTLWDLA-PTPQVRAQMASTGSICYSLALSSDAHLCLASFK-GFVEIWDVQNQ 269

  Fly   567 ILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDW 631
            ||:|:.:.....:.|:||:  |.:.||||.|.|:.|||||..::||||....:|.|:.:.|:.:|
Mouse   270 ILIRKHEVPPYASRCVDIT--GFKFWTGGEDTTLYSWDLRSYQKLQQHSLCHEILSITHDPSEEW 332

  Fly   632 LAVGMENSHVEVLHASKPDKY--------QLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTP 688
            :..|::.|.|.:|||.:.:||        |.|       :|:||:||.:|::| .|.:::....|
Mouse   333 VLAGLKMSDVVILHAHREEKYKAIVQRYTQHH-------NLKFASCGTYFMAT-LDEVIHCLAAP 389

  Fly   689 YGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            ....:||::|..::|.|::|:|::|:||||.| .||||:::|
Mouse   390 SLRRLFQAEECYNILCCEVSSDNRYLVTGSKD-SATVYQLLY 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	110/294 (37%)
		WD40 repeat	447..486	CDD:293791	15/40 (38%)
		WD40 repeat	494..532	CDD:293791	18/37 (49%)
		WD40 repeat	537..573	CDD:293791	14/35 (40%)
		WD40 repeat	580..615	CDD:293791	18/34 (53%)
		WD40 repeat	620..653	CDD:293791	12/40 (30%)
		WD40 repeat	661..695	CDD:293791	9/33 (27%)
		WD40 repeat	702..726	CDD:293791	12/23 (52%)
Tle7	NP_001357768.1	WD40	<146..422	CDD:225201	107/288 (37%)
		WD40 repeat	152..191	CDD:293791	14/38 (37%)
		WD40 repeat	199..236	CDD:293791	18/37 (49%)
		WD40 repeat	241..275	CDD:293791	14/34 (41%)
		WD40 repeat	283..316	CDD:293791	18/34 (53%)
		WD40 repeat	321..361	CDD:293791	12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D546143at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020