DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Taf5l

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001344244.1	Gene:	Taf5l / 102162	MGIID:	1919039	Length:	589	Species:	Mus musculus

Alignment Length:	307	Identity:	71/307 - (23%)
Similarity:	110/307 - (35%)	Gaps:	73/307 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 ISNPTKYVYTG-GKGCVKVWDISQPGNKNPVSQLDCL--------------QRDNY--------- 492
            ||:.:|.:..| ...|:|:|.:.....|:....:|..              :.||.
Mouse   276 ISSDSKLLAAGFDNSCIKLWSLRSKKLKSEPHHVDTSRIRLACDTLEEEENEEDNTGTEMKILRG 340

  Fly   493 ----IRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCC 553
                :.|.:.|.|...|:...|..::..|||.|.|..:..:  ..|...:.:.|||.|....|..
Mouse   341 HCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ--GHAYPVWDVDISPFSLYFASGS 403

  Fly   554 SDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSS 618
            .|....:|.......:|.:.||.....|:...|:.:.|.||..|.|||.|..::|.       |.
Mouse   404 HDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGN-------SV 461

  Fly   619 QIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLN 683
            ::|      ||                           |...||||.|:..||:..|.|:|..|.
Mouse   462 RLF------TG---------------------------HRGPVLSLSFSPNGKYLASAGEDQRLK 493

  Fly   684 AWRTPYGASIFQS--KETSSVLSCDISTDDKYIVTGSGDKKATVYEV 728
            .|....| ::|:.  ..|.|:.|...|.|...|.:.|.|....|:::
Mouse   494 LWDLASG-TLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVWDI 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	71/304 (23%)
		WD40 repeat	447..486	CDD:293791	8/34 (24%)
		WD40 repeat	494..532	CDD:293791	10/37 (27%)
		WD40 repeat	537..573	CDD:293791	8/35 (23%)
		WD40 repeat	580..615	CDD:293791	11/34 (32%)
		WD40 repeat	620..653	CDD:293791	3/32 (9%)
		WD40 repeat	661..695	CDD:293791	13/33 (39%)
		WD40 repeat	702..726	CDD:293791	6/23 (26%)
Taf5l	NP_001344244.1	TAF5_NTD2	67..201	CDD:176269
		WD 1	266..305		8/28 (29%)
		WD40	276..581	CDD:238121	71/307 (23%)
		WD 2	340..379		10/38 (26%)
		WD40 repeat	345..381	CDD:293791	10/35 (29%)
		WD 3	382..421		8/38 (21%)
		WD40 repeat	388..418	CDD:293791	7/29 (24%)
		WD 4	424..463		14/45 (31%)
		WD40 repeat	429..465	CDD:293791	13/48 (27%)
		WD 5	466..505		16/66 (24%)
		WD40 repeat	471..507	CDD:293791	14/36 (39%)
		WD 6	508..547		9/32 (28%)
		WD40 repeat	513..537	CDD:293791	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910