DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Tle7

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_017456929.1	Gene:	Tle7 / 100910419	RGDID:	6498598	Length:	437	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	141/431 - (32%)
Similarity:	232/431 - (53%)	Gaps:	57/431 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 QMMPQGPPPAGYPGAPYQRPADP----YQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGG 402
            |.||:......:.|...|...|.    .|.||. |:..| .|:..:.|:..:....|.....:|.
  Rat    22 QKMPESSGIFPHHGQQEQHQMDSAQGMLQLPPC-PSIQR-GPVCQEMHSMTQQQWDPQAQDASGL 84

  Fly   403 KPAYSFHMNGEGS---------------------------LQPV-PFPPDALVGVGIPRHARQIN 439
            :|.:......||.                           |:.: |.|.:|:|....||.:.::.
  Rat    85 QPMWFSEAEPEGGASSSFQLGDATGQFSSSSLPNREVWSFLKAIPPIPDEAVVKRKCPRGSWRVG 149

  Fly   440 TLSHGEVVCAVTISNPTKYVYTGGKGCVKVW--DISQPGNKNPVSQLDCLQRDNYIRSVKLLPDG 502
            ||.||:.|.|:.||:..::|||.|.|.::||  |.....::.|.:|||.....|.:.:.||.||.
  Rat   150 TLRHGKRVNAIAISSAPRHVYTCGTGYIRVWDEDALHASDRAPQAQLDFQDPRNRVLACKLFPDE 214

  Fly   503 RTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEI 567
            ::||.||.|..|::|||| |||:|:|::.|..|.||:||:|.|:.:|.:... |.:.:||:.|:|
  Rat   215 QSLITGGMARALTLWDLA-PTPQIRAQMASTGPICYSLALSSDAHICLASFK-GFVEIWDVQNQI 277

  Fly   568 LVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWL 632
            |:|:.:....|:.|:||:  |.:.||||.|.|:.|||||..::||||:...:|.|:.:.|:.:|:
  Rat   278 LIRKHEVPPYGSRCVDIT--GFKFWTGGEDTTLYSWDLRSYQKLQQHNLCHEILSITHDPSEEWV 340

  Fly   633 AVGMENSHVEVLHASKPDKY--------QLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPY 689
            ..|::.|.:.:|||.:.:||        |.|       :|:||:||.:|::| .|.:::....|.
  Rat   341 LAGLKMSDIVILHAHREEKYKAVVQRYTQHH-------NLKFASCGTYFMAT-LDEMIHCLAAPS 397

  Fly   690 GASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            ...:||::|...:|.||:|:|::|:|||| .:.||||:::|
  Rat   398 LRRLFQAEECYDILCCDVSSDNRYLVTGS-KESATVYQLLY 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	112/294 (38%)
		WD40 repeat	447..486	CDD:293791	15/40 (38%)
		WD40 repeat	494..532	CDD:293791	19/37 (51%)
		WD40 repeat	537..573	CDD:293791	14/35 (40%)
		WD40 repeat	580..615	CDD:293791	18/34 (53%)
		WD40 repeat	620..653	CDD:293791	11/40 (28%)
		WD40 repeat	661..695	CDD:293791	9/33 (27%)
		WD40 repeat	702..726	CDD:293791	12/23 (52%)
Tle7	XP_017456929.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D546143at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020