DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gro and Poc1b

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_002729827.2	Gene:	Poc1b / 100362836	RGDID:	2323942	Length:	477	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	79/308 - (25%)
Similarity:	130/308 - (42%)	Gaps:	30/308 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 HARQINTLSHGEVVCAVTISNPTKYVYTGGKG-CVKVWDISQPGNKN-------PVSQLDCLQRD 490
            |||....:.|.:||.::..|.....:.:..:. .|::|.:.:.|..:       ||
  Rat    50 HARAYRYVGHKDVVTSLQFSPQGNLLASASRDKTVRLWVLDRKGKSSEFKAHTAPV--------- 105

  Fly   491 NYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSD 555
               |||....||:.|:...|..::.:|.:.  ..|....|............|||.::..||..|
  Rat   106 ---RSVDFSADGQFLVTASEDKSIKVWSMY--RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSED 165

  Fly   556 GNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHD-FSSQ 619
            ..|.:||..::..|..|......|:.:|.||:|:.:.:.|.|:.||.||:|..|.||.:. .|..
  Rat   166 KTIKIWDTTSKQCVNNFSDSVGFANFVDFSPNGTCIASAGSDHAVRIWDIRMNRLLQHYQVHSCG 230

  Fly   620 IFSLGYCPTGDWLAVGMENSHVEVLHASKPDK-YQLHLHESCVLSLRFAACGKWFVSTGKDNLLN 683
            :..|.:.|:|:.|.....:..|::|...:... |.|..|...|.::.|:..|:.|.|.|.|..:.
  Rat   231 VNCLSFHPSGNSLVTASSDGTVKILDLVEGRLIYTLQGHTGPVFTVSFSKDGELFTSGGADAQVL 295

  Fly   684 AWRTPYGASIFQ--SKETSSVLSCDISTD--DKYIVT--GSGDKKATV 725
            .|||.:....::  ||.....|..:.|..  |.|..|  |..||:.|:
  Rat   296 VWRTSFNQVHYRDPSKRNLKRLHLEASPHLLDIYPRTPHGHEDKRETI 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828
		WD40	442..727	CDD:238121	76/300 (25%)
		WD40 repeat	447..486	CDD:293791	7/46 (15%)
		WD40 repeat	494..532	CDD:293791	10/37 (27%)
		WD40 repeat	537..573	CDD:293791	10/35 (29%)
		WD40 repeat	580..615	CDD:293791	14/34 (41%)
		WD40 repeat	620..653	CDD:293791	6/33 (18%)
		WD40 repeat	661..695	CDD:293791	10/33 (30%)
		WD40 repeat	702..726	CDD:293791	9/28 (32%)
Poc1b	XP_002729827.2	WD40	10..298	CDD:238121	65/261 (25%)
		WD40	14..>300	CDD:225201	67/263 (25%)
		WD40 repeat	21..58	CDD:293791	3/7 (43%)
		WD40 repeat	64..100	CDD:293791	4/35 (11%)
		WD40 repeat	105..141	CDD:293791	10/49 (20%)
		WD40 repeat	148..183	CDD:293791	10/34 (29%)
		WD40 repeat	189..225	CDD:293791	15/35 (43%)
		WD40 repeat	231..267	CDD:293791	7/35 (20%)
		WD40 repeat	273..297	CDD:293791	7/23 (30%)
		Ribosomal_S10	<331..365	CDD:294222	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910