DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gro and tle3b

DIOPT Version :9

Sequence 1:	NP_996298.1	Gene:	gro / 43162	FlyBaseID:	FBgn0001139	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_009301464.1	Gene:	tle3b / 100007463	ZFINID:	ZDB-GENE-990415-85	Length:	782	Species:	Danio rerio

Alignment Length:	823	Identity:	490/823 - (59%)
Similarity:	559/823 - (67%)	Gaps:	134/823 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVM 65
            |||.. ||||...|...| .|||:|::.:|||:||.||||||||:|:|.:||:||||||||||||
Zfish     1 MYPQG-RHPAPHQPGQPG-FKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVM 63

  Fly    66 YYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIG---- 126
            |||||||||:|||||||||||||.::.|::|||..:|||||.|||||||||||.|||.|||
Zfish    64 YYEMSYGLNIEMHKQTEIAKRLNAILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGL 128

  Fly   127 -----HQQQHGI-----QQLLQQIHAQQVPGGPP----------QPMG---------ALNPFGAL 162
                 .||.|.:     ||.||..|......|||          ||.|         .|...|||
Zfish   129 PNLPLTQQAHAVYPALMQQQLQAQHLSHAAHGPPVQLPPHPSGLQPPGIPPVTGSGSGLLALGAL 193

  Fly   163 GATMGLPHGPQGLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPAD----REKYRTRSPLDIE 223
            |:...||      :.....||  |::      ....|....|||||:|    .||:|..|...::
Zfish   194 GSQAHLP------VKDEKNHH--DLE------HRERESSTNNSVSPSDSLRASEKHRGSSEYSLD 244

  Fly   224 NDSKRRKDEK----LQEDEGEKSDQDLVVDVANE-------MESHSPRPNGEHVSMEVRDRESLN 277
             ..|||.:||    ..:.:|:||| ||||||:||       ..||||..||
Zfish   245 -PKKRRVEEKDNMSRYDSDGDKSD-DLVVDVSNEDPATPRVSPSHSPPENG-------------- 293

  Fly   278 GERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKD---MEKPGTPGAKARTPTPNAAAP----- 334
               |:|  :..:|::.|.|.:..:||.||||.|.||   .:|..|||.|:.||||...||
Zfish   294 ---LDK--ARALKKDAPNSPASVASSGSTPSSKAKDHPHNDKSSTPGLKSNTPTPRNDAPTPGTS 353

  Fly   335 -APGVNPKQMMPQG----------------PP-------------------PAGYPGAPYQRPAD 363
             .||:.|....|.|                ||                   |..|||.    ...
Zfish   354 NTPGLRPHPGKPPGMEALTAPALRTPLSIAPPYGTPFMMGHHPEMNGSLTSPGVYPGL----HIS 414

  Fly   364 PYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHP-SALTGGKPAYSFHMNGEGSLQPVPFPPDALV 427
            |.....:..||||.....:|||.|:|...:|.. :::.|||||||||::.:|.:||||||||||:
Zfish   415 PQMSAAAAAAYGRTHMPGFDPHPHMRAPVLPASLTSIPGGKPAYSFHVSADGQMQPVPFPPDALI 479

  Fly   428 GVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNY 492
            |.|||||||||||||||||||||||||||::||||||||||:|||||||:|:||||||||.||||
Zfish   480 GPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPVSQLDCLNRDNY 544

  Fly   493 IRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGN 557
            |||.||||||||||||||||.|:||||||.||||||||||:||||||||||||:|||||||||||
Zfish   545 IRSCKLLPDGRTLIVGGEASTLTIWDLASQTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGN 609

  Fly   558 IAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFS 622
            ||||||||:.||||||||||||||||||.||::||||||||||||||||||||||||||:|||||
Zfish   610 IAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFS 674

  Fly   623 LGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRT 687
            |||||||:|||||||:|:|||||.:|||||||||||||||||:||.|||||||||||||||||||
Zfish   675 LGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRT 739

  Fly   688 PYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY 730
            |||||||||||:|||||||||.|||||||||||||||||||||
Zfish   740 PYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gro	NP_996298.1	TLE_N	11..124	CDD:397828	80/112 (71%)
		WD40	442..727	CDD:238121	257/284 (90%)
		WD40 repeat	447..486	CDD:293791	33/38 (87%)
		WD40 repeat	494..532	CDD:293791	33/37 (89%)
		WD40 repeat	537..573	CDD:293791	32/35 (91%)
		WD40 repeat	580..615	CDD:293791	31/34 (91%)
		WD40 repeat	620..653	CDD:293791	27/32 (84%)
		WD40 repeat	661..695	CDD:293791	31/33 (94%)
		WD40 repeat	702..726	CDD:293791	22/23 (96%)
tle3b	XP_009301464.1	TLE_N	1..124	CDD:281857	88/124 (71%)
		Cytadhesin_P30	158..442	CDD:284643	96/322 (30%)
		WD40	<488..780	CDD:225201	264/291 (91%)
		WD40	494..779	CDD:238121	257/284 (90%)
		WD40 repeat	499..538	CDD:293791	33/38 (87%)
		WD40 repeat	546..584	CDD:293791	33/37 (89%)
		WD40 repeat	589..625	CDD:293791	32/35 (91%)
		WD40 repeat	632..667	CDD:293791	31/34 (91%)
		WD40 repeat	672..705	CDD:293791	27/32 (84%)
		WD40 repeat	713..747	CDD:293791	31/33 (94%)
		WD40 repeat	754..778	CDD:293791	22/23 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	878	1.000	Inparanoid score	I384
OMA	1	1.010	-	-		QHG48578
OrthoDB	1	1.010	-	-		D251248at33208
OrthoFinder	1	1.000	-	-		FOG0000904
OrthoInspector	1	1.000	-	-		otm25426
orthoMCL	1	0.900	-	-		OOG6_101214
Panther	1	1.100	-	-	O	PTHR10814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	12	12.480