Protein Alignment E(spl)m8-HLH and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_445780.2
• Gene: Bhlhe40 / 79431
• RGDID: 68439
• Length: 411
• Species: Rattus norvegicus
• Alignment Length: 211
• Identity: 46/211 - (21%)
• Similarity: 80/211 - (37%)
• Gaps: 69/211 - (32%)

  Fly     1 MEYTTKTQIYQ---------------KVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMD 50
            |::....|:|:               |:...::|::||.|:|:|:..||.|:.|      .|::.
  Rat    28 MDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPE------HLKLT 86

  Fly    51 KAEMLESAVIFMRQQKTPKKVA-----QEEQSLPLDS------------------FKNGYMNAVN 92
            ....||.||:.....|..|.:.     |:::.:.|.|                  |.:|:.....
  Rat    87 TLGHLEKAVVLELTLKHVKALTNLIDQQQQKIMALQSGLQAGDLSGRNIEAGQEMFCSGFQTCAR 151

  Fly    93 EVSRVMASTPGMSVDLGKS-VMTHLGRVYKNLQQFHEAQSAADFIQNSMDCSSMDKAP------- 149
            ||.:.:|.... :.||..| ::|||.||            .::.:|.|.....:|.||
  Rat   152 EVLQYLAKHEN-TRDLKSSQLVTHLHRV------------VSELLQGSASRKPLDSAPKPVDFKE 203

  Fly   150 ----LSPASSGYHSDC 161
                |:..|.|...:|
  Rat   204 KPSFLAKGSEGPGKNC 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	17/57 (30%)
		ORANGE	81..125	CDD:128787	14/62 (23%)
Bhlhe40	NP_445780.2	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		24/116 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		bHLH-O_DEC1	40..129	CDD:381592	21/94 (22%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	13/56 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..293		8/34 (24%)