DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)m8-HLH and Bhlhe41

DIOPT Version :9

Sequence 1:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_077789.1	Gene:	Bhlhe41 / 79362	MGIID:	1930704	Length:	410	Species:	Mus musculus

Alignment Length:	102	Identity:	29/102 - (28%)
Similarity:	54/102 - (52%)	Gaps:	14/102 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLE------SAVIFMRQQKTPKK 70
            |:...::|::||.|:|:|:..||.|:.|......:..::||.:||      .|:..:.:|:..|.
Mouse    46 KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKI 110

  Fly    71 VAQE--EQSL------PLDSFKNGYMNAVNEVSRVMA 99
            :|.:  |:||      .||:|.:|:.....||.:.:|
Mouse   111 IALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLA 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	17/60 (28%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	6/19 (32%)
Bhlhe41	NP_077789.1	bHLH-O_DEC2	31..122	CDD:381593	22/75 (29%)
		ORANGE	129..175	CDD:128787	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..255
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840