Protein Alignment E(spl)m8-HLH and HES4

DIOPT Version :9

• Sequence 1: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Sequence 2: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Alignment Length: 204
• Identity: 49/204 - (24%)
• Similarity: 81/204 - (39%)
• Gaps: 62/204 - (30%)

  Fly    15 KPMLERQRRARMNKCLDNLKTLVAE-LRGDDG-ILRMDKAEMLESAVIFMRQ-QKTPKKVAQEEQ 76
            ||::|::||||:|:.|..||||:.: ||.:.. ..:::||::||..|..:|. ::.....|....
Human    65 KPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSAD 129

  Fly    77 SLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQNSMD 141
            ...|..::.|:...:.||:|.:|...|:..|:...::.||....:.|.
Human   130 PAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLG----------------- 177

  Fly   142 CSSMDKAPLSPASSGYHSDCDSPAP-------------SPQPMQQP------------------- 174
             .|...|.||||     :..::|||             .|.|:..|
Human   178 -PSRRPASLSPA-----APAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQ 236

  Fly   175 ----LWRPW 179
                .||||
Human   237 GPGGPWRPW 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	21/54 (39%)
		ORANGE	81..125	CDD:128787	10/43 (23%)
HES4	NP_001135939.1	HLH	62..119	CDD:238036	21/53 (40%)
		Hairy_orange	136..174	CDD:284859	9/37 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840