DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)m8-HLH and Heyl

DIOPT Version :9

Sequence 1:NP_524513.1 Gene:E(spl)m8-HLH / 43161 FlyBaseID:FBgn0000591 Length:179 Species:Drosophila melanogaster
Sequence 2:NP_038933.2 Gene:Heyl / 56198 MGIID:1860511 Length:326 Species:Mus musculus


Alignment Length:174 Identity:33/174 - (18%)
Similarity:69/174 - (39%) Gaps:45/174 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQQKTPKKVA-QE 74
            :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::......... .:
Mouse    44 RKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFD 108

  Fly    75 EQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLG----RVYKNLQQFHEAQSAADF 135
            .::|.:|....|:...:.||.|.:....|.|        :|..    |:..:|:.:         
Mouse   109 ARALAVDFRSIGFRECLTEVIRYLGVLEGPS--------SHADPVRIRLLSHLKSY--------- 156

  Fly   136 IQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW 179
                  .:.|:.:|.:.::..:                |:| ||
Mouse   157 ------AAEMEPSPTTTSALAF----------------PVW-PW 177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)m8-HLHNP_524513.1 HLH 10..67 CDD:238036 16/55 (29%)
ORANGE 81..125 CDD:128787 10/47 (21%)
HeylNP_038933.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 2/11 (18%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 16/66 (24%)
HLH 44..100 CDD:238036 16/55 (29%)
ORANGE 115..162 CDD:128787 11/69 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..260
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..306
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830883
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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