DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)m8-HLH and Heyl

DIOPT Version :10

Sequence 1:NP_524513.1 Gene:E(spl)m8-HLH / 43161 FlyBaseID:FBgn0000591 Length:179 Species:Drosophila melanogaster
Sequence 2:NP_038933.2 Gene:Heyl / 56198 MGIID:1860511 Length:326 Species:Mus musculus


Alignment Length:174 Identity:33/174 - (18%)
Similarity:69/174 - (39%) Gaps:45/174 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQQKTPKKVA-QE 74
            :|.::.::|::||.|:|..|..|:.||.......|..:::|||:|:..|..::......... .:
Mouse    44 RKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFD 108

  Fly    75 EQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLG----RVYKNLQQFHEAQSAADF 135
            .::|.:|....|:...:.||.|.:....|.|        :|..    |:..:|:.:         
Mouse   109 ARALAVDFRSIGFRECLTEVIRYLGVLEGPS--------SHADPVRIRLLSHLKSY--------- 156

  Fly   136 IQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW 179
                  .:.|:.:|.:.::..:                |:| ||
Mouse   157 ------AAEMEPSPTTTSALAF----------------PVW-PW 177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)m8-HLHNP_524513.1 bHLH-O_ESM5_like 12..70 CDD:381486 16/57 (28%)
ORANGE 81..125 CDD:128787 10/47 (21%)
HeylNP_038933.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 2/11 (18%)
bHLH-O_HEYL 36..109 CDD:381453 16/64 (25%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 42..111 16/66 (24%)
ORANGE 115..162 CDD:128787 11/69 (16%)
PHA03247 <161..306 CDD:223021 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..260
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..306
Blue background indicates that the domain is not in the aligned region.

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